Hatano Y, Nakamura K, Yakushiji T, Nishiwada M, Mori K, Anaes F C
Department of Anesthesia, Kyoto University, Japan.
Anesthesiology. 1990 Sep;73(3):513-7. doi: 10.1097/00000542-199009000-00023.
Relaxant responses to halothane and isoflurane were compared in helical strips of dog epicardial coronary arteries of different sizes: proximal large coronary arteries with outside diameters (OD) larger than 2.5 mm and distal small arteries with 0.7-0.9 mm OD. Responses to pharmacologic vasodilators, including nitroglycerin (NTG) and adenosine, were also studied for comparison. The relaxation induced by halothane in concentrations of 0.8-2.3% and by NTG (10(-9)-10(-5) M) was greater in proximal large coronary arteries than in distal small ones contracted with 20 mM KCl. In contrast, the relaxation by isoflurane (1.2-3.5%) and by adenosine (10(-8)-10(-4) M) was greater in small coronary arteries than in large ones. These results suggest that isoflurane is, like adenosine, preferentially a small artery dilator.
外径（OD）大于2.5mm的近端大冠状动脉和外径为0.7 - 0.9mm的远端小动脉。还研究了对包括硝酸甘油（NTG）和腺苷在内的药理血管扩张剂的反应以作比较。浓度为0.8 - 2.3%的氟烷和NTG（10⁻⁹ - 10⁻⁵M）诱导的舒张在近端大冠状动脉中比在与20mM氯化钾收缩的远端小动脉中更大。相比之下，异氟烷（1.2 - 3.5%）和腺苷（10⁻⁸ - 10⁻⁴M）诱导的舒张在小冠状动脉中比在大冠状动脉中更大。这些结果表明，异氟烷与腺苷一样，优先是一种小动脉扩张剂。
