The Emergency Department of ARI Aberdeen Royal Infirmary, Aberdeen, UK.
Emerg Med J. 2011 Dec;28(12):1055-8. doi: 10.1136/emj.2010.103093. Epub 2010 Dec 23.
To review and improve the evidence base regarding the toxic effects of Mephedrone, a cathinone derivative which was first believed to have been synthesised and propagated in 2007. On the 7th April 2010 the Misuse of Drugs Act 1971 (Amendment) Order 2010 was passed, declaring 4-Methylmethcathinone and other substituted cathinones Class B drugs as of 16 April 2010. This took place despite a perceived lack of evidence as to its potential harms.
We undertook a critical review of the available literature to see what evidence existed for the potential effects of mephedrone ingestion. We then conducted our own retrospective consecutive case series of all patients presenting to the Aberdeen Royal Infirmary Emergency Department from the 1st December until the 16th April (the date at which Mephedrone was officially proscripted). The notes were examined for amounts, timings, sources and reasons for ingestion. Symptoms, biometric, ECG and blood analysis data were also recorded along with management and disposal outcomes.
11 articles relating to mephedrone toxicity were identified and reviewed. 89 subjects were found for our case series. This compared to only 27 patients presenting with ingestion of substances (heroin, cocaine, cannabis) at that time illegal. 30 patients stated ingestion of mephedrone in isolation and a further 27 patients stated ingestion of mephedrone with alcohol in addition.
A profile of largely psychoactive and cardiovascular toxicity is described with drug naivety perhaps explaining the high rates of bingeing and addiction reported.
回顾和完善关于甲卡西酮衍生物（Mephedrone）毒性作用的证据基础，这种化合物最初被认为是在 2007 年合成和传播的。2010 年 4 月 7 日，《1971 年滥用毒品法（修订）令 2010》获得通过，宣布 4-甲基甲卡西酮和其他取代的甲卡西酮为 B 类毒品，自 2010 年 4 月 16 日起生效。尽管人们对其潜在危害的认识不足，但还是采取了这一行动。
我们对现有的文献进行了批判性回顾，以了解有关 Mephedrone 摄入潜在影响的证据。然后，我们对阿伯丁皇家医院急诊部从 12 月 1 日至 4 月 16 日（Mephedrone 被正式禁止的日期）期间所有就诊的患者进行了回顾性连续病例系列研究。对摄入量、时间、来源和原因进行了检查。还记录了症状、生物计量、心电图和血液分析数据以及管理和处置结果。
确定并审查了 11 篇关于 Mephedrone 毒性的文章。我们的病例系列发现了 89 名患者。相比之下，同期只有 27 名患者因摄入非法物质（海洛因、可卡因、大麻）而就诊。30 名患者表示单独摄入 Mephedrone，另有 27 名患者表示同时摄入 Mephedrone 和酒精。
描述了一种主要表现为精神活性和心血管毒性的特征，药物新手可能解释了报告的大量狂欢和成瘾的高发生率。
