Sihvonen L, Tuomi J
Acta Vet Scand. 1978;19(2):192-203. doi: 10.1186/BF03547625.
Three series of seroepidemiological studies by microneutralization test on activity by serotypes 1, 2 and 3 of bovine adenovirus were carried out at two calf rearing farms. One farm (A) was operated as a closed, and the other (B) as an open herd. At farm A two serial studies were made, covering periods of six and nine months and including groups of 44 and 41 even-aged bull calves, respectively; at farm Β at each bleeding calves of different selected age groups were included, 36 in all. Maternal antibodies against all three types were common. With few exceptions they had disappeared at the age of five months. At farm B, unexpectedly, in view of the open herd nature, no signs of active infection were revealed during the period of study. At farm A infection by type 3 was judged to be present during both studies, though demonstrably affecting a lesser part of the study population only; infections by types 1 and 2 definitely occurred only during the second study, and then extensively. The titers of type 1 and 2 antibodies were, on the average, higher (with highest titers 1/243 and 1/729, respectively) than those of type 3 (highest titer 1/27). The spread of infection within the groups was relatively slow. A possible causative participation of type 2 virus in a smaller epidemic of mild respiratory and enteric disease at farm A was suggested but not verified by the results. Maternal antibodies did not seem to give effective protection against infection.
在两个犊牛饲养场对牛腺病毒1、2和3型的活性进行了三系列微量中和试验血清流行病学研究。一个饲养场（A）实行封闭式管理，另一个饲养场（B）实行开放式管理。在饲养场A进行了两项连续研究，分别为期6个月和9个月，分别包括44头和41头同龄公牛犊牛组；在饲养场B，每次采血时纳入了不同选定年龄组的犊牛，共36头。针对所有三种类型的母源抗体都很常见。除少数例外，它们在5个月龄时消失。在饲养场B，鉴于其开放式牛群的性质，在研究期间未发现任何主动感染的迹象，这出乎意料。在饲养场A，两项研究期间均判定存在3型感染，不过仅明显影响了研究群体中较小的一部分；1型和2型感染肯定仅在第二项研究期间发生，且感染范围广泛。1型和2型抗体的滴度平均高于3型（最高滴度分别为1/243和1/729，而3型最高滴度为1/27）。组内感染传播相对缓慢。有迹象表明2型病毒可能参与了饲养场A一场规模较小的轻度呼吸道和肠道疾病流行，但结果未得到证实。母源抗体似乎并未对感染提供有效保护。
