Key D W, Derbyshire J B
Vet Microbiol. 1984 Oct;9(6):587-92. doi: 10.1016/0378-1135(84)90021-x.
Six serum samples were taken at monthly intervals from birth to weaning from each of 41 newborn calves in the autumn and spring calf crops of a beef cow--calf herd. The serum hemagglutination-inhibition (HI) antibody titres to parainfluenza type 3 virus (PIV-3), virus-neutralization (VN) antibody titres to bovine adenovirus type 3 (BAV-3) and bovine respiratory syncytial virus (BRSV) were determined using microtitration techniques. There was serological evidence of a significantly higher incidence of infection with BAV-3 in the fall calves than in the spring calves. Serological responses to BAV-3 were not detected in calves with VN titres of greater than 1/256. Serological evidence of subclinical infection with PIV-3 occurred mainly in late February or early March during a period of marked environmental temperature fluctuations. Serological evidence of a high incidence of infection with BRSV was obtained for both the fall and spring calf crops. Serum antibody appeared to be unable to prevent infection with BRSV. An association between infection with BRSV and clinical pneumonia was found in 3 out of 9 calves. BAV-3 infection was related to pneumonia in only 1 instance; however, there was simultaneous evidence of BRSV infection in this calf. PIV-3 infection was found to be related to pneumonia in only 1 instance. There was serological evidence of infection with BAV-3 in association with the occurrence of diarrhea in 3 calves.
在一个肉牛母牛-犊牛群的秋季和春季犊牛中，从41头新生犊牛中各选取6份血清样本，从出生到断奶每月采集一次。使用微量滴定技术测定血清对3型副流感病毒（PIV-3）的血凝抑制（HI）抗体滴度、对3型牛腺病毒（BAV-3）和牛呼吸道合胞病毒（BRSV）的病毒中和（VN）抗体滴度。血清学证据表明，秋季犊牛感染BAV-3的发生率显著高于春季犊牛。VN滴度大于1/256的犊牛未检测到对BAV-3的血清学反应。PIV-3亚临床感染的血清学证据主要出现在2月下旬或3月初，此时环境温度波动明显。秋季和春季犊牛均获得了BRSV高感染率的血清学证据。血清抗体似乎无法预防BRSV感染。在9头犊牛中有3头发现BRSV感染与临床肺炎有关。BAV-3感染仅在1例中与肺炎有关；然而，这头犊牛同时有BRSV感染的证据。PIV-3感染仅在1例中与肺炎有关。有血清学证据表明，3头犊牛感染BAV-3与腹泻的发生有关。
