Gold J H, Guzman I J, Rosai J
Am J Clin Pathol. 1978 Jul;70(1):6-17. doi: 10.1093/ajcp/70.1.6.
The histologic and clinical features of 45 benign tumors of the liver (excluding hemangiomas) were reviewed. They included 21 cases of focal nodular hyperplasia, 11 cases of hepatic cell adenoma, 12 cases of bile-duct adenoma and a single case of mesenchymal hamartoma. By adhering to published histologic criteria, the cases of focal nodular hyperplasia and hepatic cell adenoma could be readily separated. Although both focal nodular hyperplasia and hepatic cell adenoma occurred predominantly in women, focal nodular hyperplasia occurred at a greater mean age, was usually asymptomatic, and the lesions tended to be smaller (surgical cases) than hepatic cell adenoma. The latter usually were symptomatic. It is emphasized that focal nodular hyperplasia and hepatic cell adenoma are distinct lesions and are separable on histologic grounds. Although the names focal nodular hyperplasia and hepatic cell adenoma are retained, the authors cannot assert that one lesion is a neoplasm, the other a reactive condition, and prefer, instead, to leave this question unresolved.
回顾了45例肝脏良性肿瘤（不包括血管瘤）的组织学和临床特征。其中包括21例局灶性结节性增生、11例肝细胞腺瘤、12例胆管腺瘤和1例间叶性错构瘤。按照已发表的组织学标准，局灶性结节性增生和肝细胞腺瘤病例能够很容易地区分开来。虽然局灶性结节性增生和肝细胞腺瘤主要发生于女性，但局灶性结节性增生的平均发病年龄更大，通常无症状，并且病变（手术病例）往往比肝细胞腺瘤小。后者通常有症状。需要强调的是，局灶性结节性增生和肝细胞腺瘤是不同的病变，在组织学基础上可区分开来。虽然保留了局灶性结节性增生和肝细胞腺瘤这两个名称，但作者无法断言一个病变是肿瘤，另一个是反应性病变，而是倾向于暂不解决这个问题。
