Knowles D M, Wolff M
Hum Pathol. 1976 Sep;7(5):533-45. doi: 10.1016/s0046-8177(76)80101-3.
We received the clinical records and pathologic material of 20 patients with biopsy proven hepatic focal nodular hyperplasia. The majority of the patients were females of child bearing age, five of whom had a history of oral use of contraceptives. In every instance focal nodular hyperplasia was an incidental finding; liver function tests were always normal. Focal nodular hyperplasia is a distinct histopathologic entity, distinguishable from liver cell adenoma. Specifically it consists of nodular aggregates of cytologically normal hepatocytes with foci of intranodular bile duct proliferation. Focal nodular hyperplasia appears to be a benign entity, even in patients in whom the lesion was not excised. The association between focal nodular hyperplasia and oral use of contraceptives may be coincidental, although hormonally related vascular changes may be responsible for rupture of the lesion.
我们收到了20例经活检证实为肝局灶性结节性增生患者的临床记录和病理材料。大多数患者为育龄女性，其中5例有口服避孕药史。在每种情况下，肝局灶性结节性增生均为偶然发现；肝功能检查始终正常。肝局灶性结节性增生是一种独特的组织病理学实体，可与肝细胞腺瘤相鉴别。具体而言，它由细胞学上正常的肝细胞结节状聚集物以及结节内胆管增生灶组成。肝局灶性结节性增生似乎是一种良性病变，即使在未切除病变的患者中也是如此。肝局灶性结节性增生与口服避孕药之间的关联可能是巧合，尽管激素相关的血管变化可能是病变破裂的原因。
