Department of Radiation Oncology, Princess Margaret Hospital, University of Toronto, 610 University Avenue, Toronto, Ontario M5G2M9, Canada.
J Neurosurg Spine. 2011 Feb;14(2):151-66. doi: 10.3171/2010.9.SPINE091005. Epub 2010 Dec 24.
Stereotactic body radiotherapy (SBRT) for spinal metastases is an emerging therapeutic option aimed at delivering high biologically effective doses to metastases while sparing the adjacent normal tissues. This technique has emerged following advances in radiation delivery that include sophisticated radiation treatment planning software, body immobilization devices, and capabilities of detecting and correcting patient positional deviations with image-guided radiotherapy. There are limited clinical data specifically supporting the role of SBRT as a superior alternative to conventional radiation in the postoperative patient. The focus of this review was to examine the evidence pertaining to spine SBRT in the treatment of spinal metastases and to provide a comprehensive analysis of published patterns of failure, with emphasis on the postoperative patient.
立体定向体部放疗（SBRT）治疗脊柱转移瘤是一种新兴的治疗选择，旨在对转移瘤给予高生物效应剂量，同时保护邻近的正常组织。这项技术是在放射治疗技术进步的基础上发展起来的，包括复杂的放射治疗计划软件、身体固定装置，以及图像引导放射治疗中检测和纠正患者位置偏差的能力。目前，只有有限的临床数据专门支持 SBRT 作为术后患者的常规放射治疗的替代方法具有优势。本综述的重点是检查与脊柱转移瘤的脊柱 SBRT 治疗相关的证据，并对已发表的失败模式进行全面分析，重点是术后患者。
