Department of Psychology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0109, USA.
Neuropsychologia. 2011 Feb;49(3):528-34. doi: 10.1016/j.neuropsychologia.2010.12.030. Epub 2010 Dec 22.
Motor and emotion processing depend on different fronto-basal ganglia circuits. Distinct sub-regions of the subthalamic nucleus (STN) may modulate these circuits. We evaluated whether stimulation targeted at separate territories in the STN region would differentially affect motor and emotion function. In a double-blind design, we studied twenty Parkinson's disease patients who had deep brain stimulation (DBS) electrodes implanted bilaterally in the STN. We stimulated either dorsal or ventral contacts of the STN electrodes on separate days in each patient and acquired behavioral measures. Dorsal contact stimulation improved motor function by reducing scores on the Unified Parkinson's Disease Rating Scale and by reducing both reaction time and reaction time variability compared to ventral contact stimulation. By contrast, ventral contact stimulation led to an increase in positive emotion compared to dorsal contact stimulation. These results support the hypothesis that different territories within the STN region implement motor and emotion functions.
运动和情绪处理依赖于不同的额基底节回路。丘脑底核（STN）的不同亚区可能调节这些回路。我们评估了针对 STN 区域不同部位的刺激是否会对运动和情绪功能产生不同的影响。在一项双盲设计中，我们研究了 20 名接受双侧 STN 深部脑刺激（DBS）电极植入的帕金森病患者。我们在每位患者的不同日子里分别刺激 STN 电极的背侧或腹侧接触点，并获取行为测量结果。与腹侧接触刺激相比，背侧接触刺激通过降低统一帕金森病评定量表的评分，以及降低反应时间和反应时间变异性，改善了运动功能。相比之下，腹侧接触刺激导致积极情绪增加，而背侧接触刺激则导致积极情绪减少。这些结果支持了这样一种假设，即 STN 区域的不同部位执行运动和情绪功能。
