Opipari A W, Boguski M S, Dixit V M
Department of Pathology, University of Michigan Medical School, Ann Arbor 48109.
J Biol Chem. 1990 Sep 5;265(25):14705-8.
We have previously identified in endothelial cells a gene product designated A20, that is rapidly and profoundly induced by tumor necrosis factor alpha (Dixit, V. M., Green, S., Sarma, V., Holzman, L. B., Wolf, F. W., O'Rourke, K., Ward, P. A., Prochownik, E. V., and Marks, R. M. (1990) J. Biol. Chem. 265, 2973-2978). Isolation of the full-length cDNA followed by sequence analysis has revealed that A20 codes for a novel zinc finger protein. Structural features suggest that this putative protein, which contains multiple Cys2/Cys2 finger motifs, defines a novel class of zinc finger proteins. Southern analysis supports the existence of other members of the class.
我们先前在内皮细胞中鉴定出一种名为A20的基因产物，它可被肿瘤坏死因子α快速且显著地诱导（迪克西特，V.M.，格林，S.，萨尔马，V.，霍尔兹曼，L.B.，沃尔夫，F.W.，奥罗克，K.，沃德，P.A.，普罗乔尼克，E.V.，以及马克斯，R.M.（1990年）《生物化学杂志》265卷，2973 - 2978页）。分离出全长互补DNA并进行序列分析后发现，A20编码一种新型锌指蛋白。结构特征表明，这种假定的蛋白质含有多个Cys2/Cys2指基序，定义了一类新型锌指蛋白。Southern印迹分析支持该类别的其他成员的存在。
