Centre des Sciences du Goût et de l'Alimentation, CNRS UMR 6265, Dijon, France.
Biol Psychol. 2011 Mar;86(3):265-72. doi: 10.1016/j.biopsycho.2010.12.007. Epub 2010 Dec 23.
Though it has been suggested that hedonic processing is altered in anorexia nervosa (AN), few studies have used objective measures to assess affective processes in this eating disorder. Accordingly, we investigated facial electromyographic, autonomic and subjective reactivity to the smell and sight of food and non-food stimuli, and assessed more particularly rapid facial reactions reflecting automatic processing of pleasantness. AN and healthy control (HC) women were exposed, before and after a standardized lunch, to pictures and odorants of foods differing in energy density, as well as to non-food sensory cues. Whereas the temporal profile of zygomatic activity in AN patients was typified by a fast drop to sensory cues within the 1000 ms following stimulus onset, HC showed a larger EMG reactivity to pictures in a 800-1000 ms time window. In contrast, pleasantness ratings discriminated the two groups only for high energy density food cues suggesting a partial dissociation between objective and subjective measures of hedonic processes in AN patients. The findings suggest that the automatic processing of pleasantness might be altered in AN, with the sensitivity to reward being modulated by controlled processes.
尽管有人提出，在神经性厌食症（AN）中，享乐加工会发生改变，但很少有研究使用客观措施来评估这种饮食失调中的情感过程。因此，我们研究了面部肌电图、自主神经系统和对食物和非食物刺激的主观反应，并特别评估了反映愉悦自动加工的快速面部反应。在标准午餐前后，AN 患者和健康对照组（HC）女性暴露于能量密度不同的食物图片和气味，以及非食物感官线索下。在 AN 患者中，颧肌活动的时间模式以刺激后 1000 毫秒内快速下降到感觉线索为特征，而 HC 在 800-1000 毫秒的时间窗口内对图片显示出更大的肌电图反应。相比之下，愉悦度评分仅能区分两组高能量密度食物线索，这表明 AN 患者的愉悦过程的客观和主观测量之间存在部分分离。研究结果表明，AN 患者的愉悦自动加工可能会发生改变，对奖励的敏感性受到控制过程的调节。
