Department of Family Medicine, Samsung Medical Center and Center for Clinical Research, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, 50 Irwondong, Gangnamgu, Seoul 135-710, South Korea.
Nutr Metab Cardiovasc Dis. 2012 Jun;22(6):503-9. doi: 10.1016/j.numecd.2010.09.004. Epub 2010 Dec 24.
We examined heritability and bivariate analyses for the Framingham Risk Score (FRS) and adiposity measures among Koreans.
We analysed the data from 2496 participants (962 men, 1534 women, age 30-74 years), including 1320 non-twin family members, 468 monozygotic (MZ) and 120 dizygotic (DZ) twin pairs, collected from the Healthy Twin study of Korea. Adiposity measurements comprised BMI, waist circumference (WC), waist-to-hip ratio and waist-to-height ratio (WHTR). Analyses were conducted using the Sequential Oligogenic Linkage Analysis Routines (SOLAR) package software. The co-twin control analyses shows that estimates of within-pair regression coefficients in the relationship between adiposity traits and FRS were attenuated for MZ twin pairs, relative to DZ twin pairs (0.11-0.26 vs. 0.60-0.71). The heritability estimate for FRS was 0.37, and the estimates for adiposity traits ranged from 0.45 to 0.63 (P < 0.001). Bivariate analysis revealed genetic correlations between FRS, and all of the adiposity traits ranged from 0.16 (for WHTR, P > 0.05) to 0.46 (for WC, P < 0.001). The common environmental correlations between FRS and each of the adiposity traits ranged from 0.43 to 0.66 (P < 0.001).
FRS and each of the obesity traits shared common genetic and environmental relationships. These findings support a pleiotropic action between genes associated with adiposity traits and FRS and a need of further investigations for identifying specific common environmental factors.
我们研究了韩国人群中弗雷明汉风险评分（Framingham Risk Score，FRS）和肥胖指标的遗传度和双变量分析。
我们分析了来自韩国健康双胞胎研究的 2496 名参与者（962 名男性，1534 名女性，年龄 30-74 岁）的数据，其中包括 1320 名非双胞胎家庭成员、468 对同卵（MZ）和 120 对异卵（DZ）双胞胎。肥胖测量包括 BMI、腰围（WC）、腰臀比和腰高比（WHTR）。分析使用了序列连锁分析程序（Sequential Oligogenic Linkage Analysis Routines，SOLAR）软件包。同卵双胞胎对照分析显示，与 DZ 双胞胎相比，MZ 双胞胎中肥胖特征与 FRS 之间的个体内回归系数估计值减弱（0.11-0.26 对 0.60-0.71）。FRS 的遗传度估计值为 0.37，肥胖特征的估计值范围为 0.45-0.63（P<0.001）。双变量分析显示，FRS 与所有肥胖特征之间存在遗传相关性，范围从 0.16（WHTR，P>0.05）到 0.46（WC，P<0.001）。FRS 与每个肥胖特征之间的共同环境相关性范围从 0.43 到 0.66（P<0.001）。
FRS 和每个肥胖特征都存在共同的遗传和环境关系。这些发现支持了与肥胖特征和 FRS 相关的基因之间存在多效性作用，需要进一步研究以确定特定的共同环境因素。
