[Effect of thrombolytic, anticoagulant and anti-thrombocytic therapy on the development of left-ventricular thrombosis and the incidence of thromboembolic complications in patients with myocardial infarction].

To reveal the effects produced by thrombolytic and anticoagulative therapies on the formation of left ventricular mural thrombosis (LVT) and the frequency of thromboembolic events, a prospective randomized study was performed in 285 patients with primary transmural myocardial infarction. LVT was diagnosed from the serial two-dimensional echocardiographic findings. No significant effect of the therapy with thrombolytic and anticoagulative agents was found on the incidence and periods of intracavitary LVT development. There was a significant reduction in the incidence of LVT during early (less than 3 hours) reperfusion of the occluded coronary artery. Anticoagulative and antiplatelet therapies performed within the first month of myocardial infarction decrease the risk for systemic thromboembolism in patients with diagnosed LVT.