Service of Neurology, Department of Clinical Neurosciences, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.
J Neuroimmunol. 2011 Apr;233(1-2):240-4. doi: 10.1016/j.jneuroim.2010.11.008. Epub 2010 Dec 24.
Little is known on a putative effect of vitamin D on CD8+ T cells. Yet, these cells are involved in the immmunopathogenesis of MS. We assessed the cytokine profile of EBV-specific CD8+ T cells of 10 early MS patients and 10 healthy control subjects with or without 1,25(OH)(2)D(3) and found that, with 1,25(OH)(2)D(3), these cells secreted less IFN-γ and TNF-α and more IL-5 and TGF-β. CD4+ T cell depletion or even culture with CD8+ T cells only did not abolish the immunomodulatory effect of 1,25(OH)(2)D(3) on CD8+ T cells, suggesting that 1,25(OH)(2)D(3) can act directly on CD8+ T cells.
关于维生素 D 对 CD8+T 细胞的潜在作用知之甚少。然而，这些细胞参与了多发性硬化症的免疫发病机制。我们评估了 10 名早期多发性硬化症患者和 10 名健康对照者的 EBV 特异性 CD8+T 细胞的细胞因子谱，结果发现，在添加 1,25(OH)（2）D（3）的情况下，这些细胞分泌的 IFN-γ 和 TNF-α减少，而 IL-5 和 TGF-β增加。CD4+T 细胞耗竭甚至仅用 CD8+T 细胞培养也不能消除 1,25(OH)（2）D（3）对 CD8+T 细胞的免疫调节作用，这表明 1,25(OH)（2）D（3）可以直接作用于 CD8+T 细胞。
