硫酸锌对肠系膜上动脉闭塞（SMAO）休克期间肺损伤的治疗作用
[Therapeutic effect of zinc sulfate on lung injury during superior mesenteric artery occlusion(SMAO) shock].
作者信息
Jing You-Ling, Zhao Chun-Xiu, Duan Guo-Xian, Wang Yan-Lei, Hu Yong-Qi, Zhang Lian-Yuan
机构信息
Department of Physiology, North Coal Medical College, Tangshan 063000, China.
出版信息
Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2006 Feb;22(1):90-3.
AIM
To study preventive and therapeutic effect of zinc sulfate on lung injury during superior mesenteric artery occlusion (SMAO) shock and their mechanism of action.
METHODS
Model of rabbit SMAO shock was made. The effect of zinc sulfate on the malondialdehyde (MDA) in erythrocyte membrane and plasma, oxidase (XOD) in plasma, superoxide dismutase (SOD) in erythrocyte and MDA, SOD and pulmonary surfactant (PS) in lung tissues homogenate were observed.
RESULTS
The administration of zinc sulfate decreased MDA and XOD, prevented the reduction of SOD and PS, and alleviated lung injury.
CONCLUSION
It is suggested that lung is injured during SMAO shock and zinc sulfate possesses preventive and therapeutic effect, through stabilized membrane.
目的
研究硫酸锌对上肠系膜动脉闭塞（SMAO）休克时肺损伤的防治作用及其作用机制。
方法
制作兔SMAO休克模型。观察硫酸锌对红细胞膜和血浆中丙二醛（MDA）、血浆中氧化酶（XOD）、红细胞中超氧化物歧化酶（SOD）以及肺组织匀浆中MDA、SOD和肺表面活性物质（PS）的影响。
结果
给予硫酸锌可降低MDA和XOD，防止SOD和PS降低，并减轻肺损伤。
结论
提示SMAO休克时肺脏受到损伤，硫酸锌具有防治作用，其机制可能与稳定细胞膜有关。
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