[黄芪和硫酸锌对肠缺血再灌注损伤时红细胞膜黏度的影响]
[Influence of astragalus and zinc sulfate on the viscosity in erythrocyte membrane during intestinal ischemia - reperfusion(I/R) injury].
作者信息
Zhao Chun-Xiu, Jing You-Ling, Chai Lian-Fei, Duan Guo-Xian, Li Hong-Jie, Zhang Shuo-Sen, Cui He-Qin
机构信息
Department of Physiology of North China Coal Medical College, Tangshan 063000, China.
出版信息
Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2003 Aug;19(3):213-5.
AIM
To study the influence of astragalus and zinc sulfate on the viscosity in erythrocyte membrane during intestinal I/R and their mechanism of action.
METHODS
Models of rabbits intestinal I/R injury were made. The effect of astragalus and zinc sulfate on the viscosity and malondialdehyde (MDA) in erythrocyte membrane, superoxide dismutase (SOD) in erythrocyte, oxidase (XO) in plasma and MDA tissues homogenate were observed.
RESULTS
The administration of astragalus and zinc sulfate decreased viscosity and MDA and XO, prevented the reduction of SOD, and alleviated I/R injury.
CONCLUSION
Lipid peroxidation injury of the erythrocyte membrane was one of the pathogenesis of I/R injury, and astragalus and the zinc sulfate possessed effects of anti-lipid peroxide, stabilized erythrocyte membrane, increased red blood cell deform ability and raised microcircular perfusion.
目的
研究黄芪和硫酸锌对肠缺血再灌注时红细胞膜黏度的影响及其作用机制。
方法
制备家兔肠缺血再灌注损伤模型。观察黄芪和硫酸锌对红细胞膜黏度、丙二醛（MDA）、红细胞超氧化物歧化酶（SOD）、血浆氧化酶（XO）及组织匀浆MDA的影响。
结果
黄芪和硫酸锌给药后降低了黏度、MDA和XO，防止了SOD的降低，并减轻了缺血再灌注损伤。
结论
红细胞膜脂质过氧化损伤是缺血再灌注损伤的发病机制之一，黄芪和硫酸锌具有抗脂质过氧化、稳定红细胞膜、增加红细胞变形能力及提高微循环灌注的作用。
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