意大利献血者中丙型肝炎病毒抗体的流行情况。意大利合作组

Prevalence of hepatitis C virus antibodies in Italian blood donors. The Italian Cooperative Group.

作者信息

Sirchia G, Almini D, Bellobuono A, Giovanetti A M, Marconi M, Mercuriali F, Mozzi F, Parravicini A, Pizzi M, Zanuso F

机构信息

Centro Trasfusionale e di Immunologia dei Trapianti, Ospedale Maggiore, Milano, Italia.

出版信息

Vox Sang. 1990;59(1):26-9. doi: 10.1111/j.1423-0410.1990.tb02109.x.

DOI:10.1111/j.1423-0410.1990.tb02109.x

PMID:2118697

Abstract

11,117 blood donors from 24 blood transfusion services evenly distributed throughout the various Italian regions were tested for the presence of hepatitis C virus (HCV) antibodies in the serum and serum alanine aminotransferase (ALT) level. The results are as follows: (1) anti-HCV seroprevalence in Italy was 0.87% with a difference between Northern and Southern regions (0.68 vs. 1.37%) and between younger and older subjects (0.62 vs. 1.21%); (2) prevalence of elevated ALT levels was 4.74% without a North-South effect (except than for markedly elevated ALT levels); (3) anti-HCV seroprevalence was higher in subjects with elevated ALT (5.0%), with a North-South effect (2.2 vs. 9.9%) and particularly high (19.2%) in subjects with markedly elevated ALT; (4) ALT levels were elevated in 26.2% of anti-HCV positive subjects, with a North-South effect (14 vs. 40.5%).

摘要

来自意大利各地区24家输血服务机构的11117名献血者接受了血清丙型肝炎病毒（HCV）抗体和血清丙氨酸氨基转移酶（ALT）水平检测。结果如下：（1）意大利抗-HCV血清阳性率为0.87%，北部和南部地区之间存在差异（分别为0.68%和1.37%），年轻和年长受试者之间也存在差异（分别为0.62%和1.21%）；（2）ALT水平升高的患病率为4.74%，不存在南北差异（除ALT水平显著升高外）；（3）ALT升高的受试者中抗-HCV血清阳性率更高（5.0%），存在南北差异（分别为2.2%和9.9%），在ALT水平显著升高的受试者中尤其高（19.2%）；（4）抗-HCV阳性受试者中26.2%的ALT水平升高，存在南北差异（分别为14%和40.5%）。