抗-HCV阳性受试者配偶及子女中抗-HCV的流行情况：一项意大利多中心研究。
Prevalence of anti-HCV among spouses and offspring of anti-HCV positive subjects: an Italian multicentre study.
作者信息
Caporaso N, Ascione A, D'Antonio M, Di Costanzo G G, Galeota Lanza A, Tremolada F, Diodati G, Rumi M G, Parravicini M L, Pastore G
机构信息
Dipartimento di Internistica, Clinica F Magrassi, II Università di Napoli, Italy.
出版信息
Ital J Gastroenterol. 1995 Jan-Feb;27(1):5-7.
The role of familial environment in the spreading of hepatitis C virus (HCV) infection is not well established. We studied 1670 family members for 578 anti-HCV+ subjects enrolled in 8 centres distributed throughout Italy. The prevalence of anti-HCV positivity was significantly higher in spouses than in offspring (15.6% and 2.1% respectively; p < 0.01), with no difference between northern and central-southern regions of Italy. Anti-HCV positivity was found almost exclusively in adults; among offspring, during the first two decades of life, the prevalence of anti-HCV positivity was significantly lower than in subjects over 20 years old (0.6% vs 3.1%, respectively).
家庭环境在丙型肝炎病毒（HCV）感染传播中的作用尚未完全明确。我们对分布在意大利各地8个中心的578名抗-HCV阳性受试者的1670名家庭成员进行了研究。配偶中抗-HCV阳性的患病率显著高于后代（分别为15.6%和2.1%；p<0.01），意大利北部和中南部地区之间无差异。抗-HCV阳性几乎仅在成年人中发现；在后代中，在生命的前二十年，抗-HCV阳性的患病率显著低于20岁以上的受试者（分别为0.6%和3.1%）。
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