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1
Leptin at 14 y of age: an ongoing story.14岁时的瘦素：一个仍在继续的故事。
Am J Clin Nutr. 2009 Mar;89(3):973S-979S. doi: 10.3945/ajcn.2008.26788B. Epub 2009 Feb 3.
2
Structural basis for the activation of PPARgamma by oxidized fatty acids.氧化脂肪酸激活过氧化物酶体增殖物激活受体γ的结构基础。
Nat Struct Mol Biol. 2008 Sep;15(9):924-31. doi: 10.1038/nsmb.1474.
3
Leptin and cardiovascular disease: response to therapeutic interventions.瘦素与心血管疾病：对治疗干预的反应
Circulation. 2008 Jun 24;117(25):3238-49. doi: 10.1161/CIRCULATIONAHA.107.741645.
4
Leptin deficiency suppresses progression of atherosclerosis in apoE-deficient mice.瘦素缺乏抑制载脂蛋白E缺乏小鼠的动脉粥样硬化进展。
Atherosclerosis. 2008 Jan;196(1):68-75. doi: 10.1016/j.atherosclerosis.2007.01.040. Epub 2007 Mar 23.
5
Role of leptin in blood pressure regulation and arterial hypertension.瘦素在血压调节和动脉高血压中的作用。
J Hypertens. 2006 May;24(5):789-801. doi: 10.1097/01.hjh.0000222743.06584.66.
6
Leptin receptors are expressed in coronary arteries, and hyperleptinemia causes significant coronary endothelial dysfunction.瘦素受体在冠状动脉中表达，高瘦素血症会导致严重的冠状动脉内皮功能障碍。
Am J Physiol Heart Circ Physiol. 2005 Jul;289(1):H48-56. doi: 10.1152/ajpheart.01159.2004. Epub 2005 Mar 4.
7
Regulation of leptin secretion from white adipocytes by free fatty acids.游离脂肪酸对白色脂肪细胞瘦素分泌的调节。
Am J Physiol Endocrinol Metab. 2003 Sep;285(3):E521-6. doi: 10.1152/ajpendo.00052.2003. Epub 2003 May 7.
8
The relationship between leptin and lipids in atherosclerosis.瘦素与动脉粥样硬化中脂质的关系。
Indian Heart J. 2002 Nov-Dec;54(6):692-6.
9
Oxidized fatty acids promote atherosclerosis only in the presence of dietary cholesterol in low-density lipoprotein receptor knockout mice.在低密度脂蛋白受体基因敲除小鼠中，氧化脂肪酸仅在膳食胆固醇存在的情况下促进动脉粥样硬化。
J Nutr. 2002 Nov;132(11):3256-62. doi: 10.1093/jn/132.11.3256.
10
The impact of dietary fat composition on serum leptin concentrations in healthy nonobese men and women.饮食脂肪组成对健康非肥胖男性和女性血清瘦素浓度的影响。
J Clin Endocrinol Metab. 2002 Nov;87(11):5008-14. doi: 10.1210/jc.2002-020496.

氧化亚油酸对瘦素水平的调节：与动脉粥样硬化有关？

Modulation of leptin levels by oxidized linoleic acid: a connection to atherosclerosis?

机构信息

Division of Nutrition, School of Health Professions, Georgia State University, Atlanta, Georgia, USA.

出版信息

J Med Food. 2011 Apr;14(4):441-3. doi: 10.1089/jmf.2010.0059. Epub 2010 Dec 27.

DOI:10.1089/jmf.2010.0059
PMID:21186986
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3123838/
Abstract

The objective of the study was to determine the effects of oxidized linoleic acid (Ox-LA) on plasma leptin and to determine the relationship between plasma leptin levels and atherosclerosis in animals treated with Ox-LA. Low-density lipoprotein (LDL) receptor knockout (LDL r(-/-)) mice were fed a high fat diet with or without Ox-LA for 11 weeks. Plasma leptin levels in the high fat group consuming Ox-LA were significantly higher (14,052 ± 601 pg/mL vs. 10,950 ± 541 pg/mL; P < .01) compared to the group receiving the high fat diet alone. There was a highly significant correlation between the plasma leptin levels and aortic atherosclerotic lesions. From this we conclude that chronic exposure to dietary Ox-LA increases the plasma levels of leptin in LDL r(-/-) mice on a high fat diet. Considering our previous finding that dietary Ox-LA increased atherosclerosis, the current findings emphasize the need to reduce dietary intake of oxidized fat.

摘要

本研究旨在确定氧化亚油酸（Ox-LA）对血浆瘦素的影响，并确定在给予 Ox-LA 的动物中血浆瘦素水平与动脉粥样硬化之间的关系。用高脂饮食喂养载脂蛋白 E 基因敲除（apoE(-/-)) 小鼠，同时给予或不给予 Ox-LA，共 11 周。高脂饮食组中摄入 Ox-LA 的血浆瘦素水平显著升高（14052±601 pg/ml 比 10950±541 pg/ml；P<0.01）。血浆瘦素水平与主动脉粥样硬化病变之间存在高度显著的相关性。由此我们得出结论，慢性摄入膳食 Ox-LA 可增加高脂饮食的 apoE(-/-) 小鼠血浆瘦素水平。考虑到我们之前发现膳食 Ox-LA 可增加动脉粥样硬化，目前的发现强调需要减少膳食氧化脂肪的摄入。