Badalian S S, Mikhaĭlov A V
Akush Ginekol (Mosk). 1990 May(5):55-8.
Renin activity and aldosterone concentrations have been determined in amniocentesis samples and fetal plasma obtained by intrauterine umbilical vein puncture in 23 women at 25 to 34 weeks' gestation, normal or complicated by hemolytic disease of the fetus. Prior to the intrauterine interventions, Doppler studies of umbilical arterial circulation were done and 1-hour fetal diuresis was measured. Fetal plasma pH and fetoplacental flood volume were determined. Hemolytic disease was shown to increase renin activity and aldosterone concentration in the amniotic fluid and fetal plasma in parallel with reduction in the fetoplacental blood flow and 1-hour fetal diuresis, increase in vascular resistance of fetal placenta and hypoxia. The increase in renin-aldosterone activity of the fetoplacental unit may be a compensatory fetal and chorionic response to hemodynamic and water-mineral balance in the presence of impaired uteroplacental circulation.
对23名妊娠25至34周、胎儿正常或并发溶血病的孕妇，测定了羊膜腔穿刺样本及经子宫内脐静脉穿刺获取的胎儿血浆中的肾素活性和醛固酮浓度。在进行子宫内干预之前，进行了脐动脉循环的多普勒研究，并测量了1小时胎儿尿量。测定了胎儿血浆pH值和胎儿-胎盘血流量。结果显示，溶血病会使羊水和胎儿血浆中的肾素活性和醛固酮浓度升高，同时伴有胎儿-胎盘血流量减少和1小时胎儿尿量减少、胎儿胎盘血管阻力增加及缺氧。胎儿-胎盘单位肾素-醛固酮活性的增加可能是胎儿和绒毛膜在子宫胎盘循环受损时对血液动力学和水-矿物质平衡的一种代偿反应。
