下调 Mus81 作为胃癌恶性肿瘤的潜在标志物。
Down-regulation of Mus81 as a potential marker for the malignancy of gastric cancer.
机构信息
Department of General Surgery, Guangzhou Red Cross Hospital, Fourth Affiliated Hospital of Jinan University, Guangzhou, China.
出版信息
Anticancer Res. 2010 Dec;30(12):5011-4.
BACKGROUND
The Mus81 gene encodes a critical endonuclease involved in DNA repair and tumor suppression. In the present study, the role of Mus81 in gastric cancer was explored.
MATERIALS AND METHODS
Mus81 expression in 53 cases of gastric cancer and the corresponding normal tissues was determined by quantitative real-time PCR. The correlations between Mus81 down-regulation and the clinicopathological data were also evaluated.
RESULTS
Mus81 expression was significantly lower in gastric cancer tissues than the corresponding normal tissues (p = 0.018) and the down-regulation of Mus81 occurred in 51% (27/53) of the gastric carcinomas. More importantly, Mus81 down-regulation correlated significantly to invasion depth (p = 0.015) and poorly-differentiated type (p = 0.016) of gastric cancer.
CONCLUSION
Mus81 might be a potential marker for the malignancy of gastric cancer.
背景
Mus81 基因编码一种在 DNA 修复和肿瘤抑制中起关键作用的内切酶。本研究探讨了 Mus81 在胃癌中的作用。
材料与方法
采用实时定量 PCR 检测 53 例胃癌及相应正常组织中 Mus81 的表达情况，并评估 Mus81 下调与临床病理资料的相关性。
结果
胃癌组织中 Mus81 的表达明显低于相应的正常组织（p = 0.018），在 53 例胃癌中，有 51%（27/53）发生 Mus81 下调。更重要的是，Mus81 下调与胃癌的浸润深度（p = 0.015）和低分化类型（p = 0.016）显著相关。
结论
Mus81 可能是胃癌恶性程度的一个潜在标志物。
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