Rellahan B L, Cone R E
Department of Pathology, University of Connecticut Health Center, Farmington 06032.
Cell Immunol. 1990 Oct 1;130(1):176-85. doi: 10.1016/0008-8749(90)90171-m.
The ontogeny of T cells which express major histocompatibility complex (MHC)-unrestricted T cell antigen-binding molecules (TABM) on the cell membrane was investigated. We used a rabbit anti-mouse TABM antiserum to investigate the expression of TABM by subsets of adult thymocytes, peripheral T cells, and thymocytes during gestation. TABM are expressed by CD4+, CD8-, CD4+, CD8+ thymocytes and single-positive thymocytes. During gestation, TABM are expressed as early as Day 16, and at birth the expression of TABM on thymocytes has reached adult levels. Data are also presented which suggest that the expression of membrane TABM (mTABM) on peripheral T cells can be upregulated during T cell activation. The results suggest that TABM are expressed by different T cell subsets and that TABM+ cells may utilize the same intrathymic developmental pathway as that of T cells which express the alpha/beta T cell receptor.
我们研究了细胞膜上表达主要组织相容性复合体（MHC）非限制性T细胞抗原结合分子（TABM）的T细胞的个体发生。我们使用兔抗小鼠TABM抗血清来研究成年胸腺细胞亚群、外周T细胞以及妊娠期间胸腺细胞中TABM的表达情况。TABM由CD4⁺、CD8⁻、CD4⁺、CD8⁺胸腺细胞以及单阳性胸腺细胞表达。在妊娠期间，TABM最早在第16天表达，出生时胸腺细胞上TABM的表达已达到成年水平。同时还呈现了一些数据，表明外周T细胞上膜TABM（mTABM）的表达在T细胞活化过程中可被上调。结果表明TABM由不同的T细胞亚群表达，并且TABM⁺细胞可能与表达α/βT细胞受体的T细胞利用相同的胸腺内发育途径。
