Department of Health, Feira de Santana State University, Feira de Santana, BA, Brazil.
J Periodontol. 2011 Jul;82(7):969-78. doi: 10.1902/jop.2010.100511. Epub 2010 Dec 28.
This study aims to analyze the relationship between chronic periodontitis and C-reactive protein (CRP) by considering associated variables in individuals with or without cardiovascular disease.
A sample of 359 individuals of both sexes (aged ≥40 years) was assessed. Among these individuals, 144 subjects were admitted to the hospital because of a first occurrence of acute myocardial infarction; 80 subjects were in the hospital for reasons other than acute myocardial infarction; and 135 subjects were living in the community. A questionnaire was applied to obtain demographic and lifestyle characteristics. Complete clinical periodontal examinations and anthropometric assessments were performed. CRP levels, plasma glucose levels, lipid profiles, and blood tests were performed to investigate any conditions that might have suggested infection and/or inflammation. CRP evaluations were performed using nephelometry. Individuals were considered to have periodontal disease if they simultaneously presented at least four teeth with one or more sites with probing depth ≥4 mm, clinical attachment loss ≥3 mm, and bleeding on probing. Procedures for descriptive analyses and logistic regression were used.
In the chronic periodontitis group, mean CRP levels were higher than those in the group without chronic periodontitis (2.6 ± 2.6 mg/L versus 1.78 ± 2.7 mg/L, respectively). The final model showed that individuals with chronic periodontitis were more likely to have high CRP levels (adjusted odds ratio: 2.26; 95% confidence interval: 1.30 to 3.93) considering the effects of age, schooling level, sex, smoking, high-density lipoprotein cholesterol, and diabetes.
In this study, chronic periodontitis is associated with elevated plasma CRP levels, even after controlling for several potential confounders.
本研究旨在分析慢性牙周炎与 C 反应蛋白（CRP）之间的关系，并考虑患有或不患有心血管疾病的个体的相关变量。
评估了 359 名男女个体（年龄≥40 岁）的样本。在这些个体中，144 名患者因首次发生急性心肌梗死而住院；80 名患者因非急性心肌梗死住院；135 名患者居住在社区。应用问卷调查获得人口统计学和生活方式特征。进行了完整的临床牙周检查和人体测量评估。进行了 CRP 水平、血浆葡萄糖水平、血脂谱和血液检查，以调查任何可能提示感染和/或炎症的情况。使用散射比浊法进行 CRP 评估。如果同时有至少四颗牙齿的一个或多个位点的探诊深度≥4 毫米、临床附着丧失≥3 毫米和探诊出血，则认为个体患有牙周病。使用描述性分析和逻辑回归程序。
在慢性牙周炎组中，CRP 水平的平均值高于无慢性牙周炎组（2.6±2.6 mg/L 比 1.78±2.7 mg/L）。最终模型显示，考虑到年龄、教育程度、性别、吸烟、高密度脂蛋白胆固醇和糖尿病的影响，患有慢性牙周炎的个体更有可能具有较高的 CRP 水平（调整后的优势比：2.26；95%置信区间：1.30 至 3.93）。
在这项研究中，即使在控制了几个潜在的混杂因素后，慢性牙周炎与血浆 CRP 水平升高有关。
