Zhang Haocheng, Yu Qian, Ying Caidi, Liu Yibo, Wang Xiaoyu, Guo Yinghan, Xu Liang, Fang Yuanjian, Liao Xiaoyue, Chen Sheng
Department of Neurosurgery, School of Medicine, The Second Affiliated Hospital, Zhejiang University, Zhejiang Province, Hangzhou, China.
Key Laboratory of Precise Treatment and Clinical Translational Research of Neurological Diseases, Hangzhou, Zhejiang, China.
Saudi Dent J. 2024 Nov;36(11):1389-1396. doi: 10.1016/j.sdentj.2024.09.012. Epub 2024 Sep 10.
This study aimed to analyze the existing evidence on the association between dental diseases and stroke. Various pathogenic mechanisms, including bacteraemia and systemic inflammation, were investigated to explore their impact on stroke occurrence and severity.
A comprehensive literature search was conducted through the online databases PubMed, Google Scholar, Web of Science, and Scopus. The initial screening process resulted in a total of 138 articles being gathered. Upon subsequent refinement, 52 articles were discarded due to duplication or non-English language, leaving 86 articles for further assessment.
Oral bacteria can travel to the brain's blood vessels and cause bacteraemia, leading to local inflammation and the release of toxins. This process can result in the blockage or rupture of blood vessels, leading to stroke. Oral infections consistently trigger immune responses and systemic inflammation, with inflammation-related proteins playing a crucial role in stroke development. Notably, periodontal treatment could reduce the risk of stroke.
This review emphasizes the role of dental diseases in promoting stroke occurrence through various mechanisms. Dental diseases contribute to the development of stroke by facilitating bacteraemia and systemic inflammation. Furthermore, through effectively treating and preventing dental diseases, the risk of strokes can be significantly reduced.
本研究旨在分析关于牙科疾病与中风之间关联的现有证据。研究了包括菌血症和全身炎症在内的各种致病机制，以探讨它们对中风发生和严重程度的影响。
通过在线数据库PubMed、谷歌学术、科学网和Scopus进行了全面的文献检索。初步筛选过程共收集到138篇文章。经过后续筛选，由于重复或非英文语言原因，丢弃了52篇文章，剩下86篇文章进行进一步评估。
口腔细菌可进入大脑血管并导致菌血症，引发局部炎症和毒素释放。这一过程可导致血管阻塞或破裂，进而引发中风。口腔感染持续引发免疫反应和全身炎症，与炎症相关的蛋白质在中风发展中起关键作用。值得注意的是，牙周治疗可降低中风风险。
本综述强调了牙科疾病通过多种机制促进中风发生的作用。牙科疾病通过促进菌血症和全身炎症导致中风的发生。此外，通过有效治疗和预防牙科疾病，可显著降低中风风险。
