文献检索文档翻译深度研究
Suppr Zotero 插件Zotero 插件
邀请有礼套餐&价格历史记录

新学期，新优惠

限时优惠:9月1日-9月22日

30天高级会员仅需29元

1天体验卡首发特惠仅需5.99元

了解详情
不再提醒
插件&应用
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
高级版
套餐订阅购买积分包
AI 工具
文献检索文档翻译深度研究
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2025

牙周病与阿尔茨海默病之间的相互作用：对相互触发、病情加重及治疗干预的影响——文献综述

Reciprocal Interactions Between Periodontal Disease and Alzheimer's Disease: Implications for Mutual Triggering, Exacerbation, and Treatment Interventions-A Comprehensive Review of the Literature.

作者信息

Gharaibeh Shatha, Alsabbah Alameen, Alloubani Ahmad, Gharaibeh Abeer

机构信息

Division of Periodontics, Ministry of Health, Amman 11118, Jordan.

Insight Research Institute, Flint, MI 48507, USA.

出版信息

Neurol Int. 2025 May 24;17(6):81. doi: 10.3390/neurolint17060081.

DOI:10.3390/neurolint17060081
PMID:40559320
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12196369/
Abstract

Periodontal health is connected to many systemic diseases, such as cardiovascular, diabetes mellitus, and neurodegenerative diseases. The oral-brain axis has gained increasing interest in the pathogenesis of diseases. Emerging studies have highlighted the potential role of periodontal disease in the development and progression of Alzheimer's disease. However, Alzheimer's disease also affects periodontal disease and oral health. In this review, we address the correlation between the two diseases and the mechanisms by which one contributes to the other. Exploring the correlation between Alzheimer's disease and periodontal disease will assist in better understanding the pathophysiology of diseases and pave the way for the development of therapeutic and preventive strategies.

摘要

牙周健康与许多全身性疾病相关，如心血管疾病、糖尿病和神经退行性疾病。口腔-脑轴在疾病的发病机制中越来越受到关注。新兴研究强调了牙周病在阿尔茨海默病发展和进展中的潜在作用。然而，阿尔茨海默病也会影响牙周病和口腔健康。在本综述中，我们阐述了这两种疾病之间的相关性以及一种疾病影响另一种疾病的机制。探索阿尔茨海默病与牙周病之间的相关性将有助于更好地理解疾病的病理生理学，并为治疗和预防策略的开发铺平道路。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3541/12196369/25e0aa84833f/neurolint-17-00081-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3541/12196369/978039f145cf/neurolint-17-00081-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3541/12196369/377b3b0a3ac6/neurolint-17-00081-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3541/12196369/25e0aa84833f/neurolint-17-00081-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3541/12196369/978039f145cf/neurolint-17-00081-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3541/12196369/377b3b0a3ac6/neurolint-17-00081-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3541/12196369/25e0aa84833f/neurolint-17-00081-g003.jpg

相似文献

[1]
Reciprocal Interactions Between Periodontal Disease and Alzheimer's Disease: Implications for Mutual Triggering, Exacerbation, and Treatment Interventions-A Comprehensive Review of the Literature.

Neurol Int. 2025-5-24

[2]
Treatment of periodontitis for glycaemic control in people with diabetes mellitus.

Cochrane Database Syst Rev. 2022-4-14

[3]
CSF tau and the CSF tau/ABeta ratio for the diagnosis of Alzheimer's disease dementia and other dementias in people with mild cognitive impairment (MCI).

Cochrane Database Syst Rev. 2017-3-22

[4]
Should We Be Concerned about the Association of Diabetes Mellitus and Periodontal Disease in the Risk of Infection by SARS-CoV-2? A Systematic Review and Hypothesis.

Medicina (Kaunas). 2021-5-13

[5]
18F PET with florbetapir for the early diagnosis of Alzheimer's disease dementia and other dementias in people with mild cognitive impairment (MCI).

Cochrane Database Syst Rev. 2017-11-22

[6]
Periodontal therapy for primary or secondary prevention of cardiovascular disease in people with periodontitis.

Cochrane Database Syst Rev. 2022-10-4

[7]
Supportive periodontal therapy (SPT) for maintaining the dentition in adults treated for periodontitis.

Cochrane Database Syst Rev. 2018-1-1

[8]
Donepezil for dementia due to Alzheimer's disease.

Cochrane Database Syst Rev. 2018-6-18

[9]
Systemic treatments for metastatic cutaneous melanoma.

Cochrane Database Syst Rev. 2018-2-6

[10]
The Interplay Between Exosomes and Gut Microbiota in Neuroinflammation: A New Frontier in Alzheimer's Disease.

Int J Mol Sci. 2025-6-18

本文引用的文献

[1]
Diagnosis of Alzheimer's disease using plasma biomarkers adjusted to clinical probability.

Nat Aging. 2024-11

[2]
Interconnections between the Gut Microbiome and Alzheimer's Disease: Mechanisms and Therapeutic Potential.

Int J Mol Sci. 2024-8-7

[3]
Recent advances in Alzheimer's disease: Mechanisms, clinical trials and new drug development strategies.

Signal Transduct Target Ther. 2024-8-23

[4]
Systemic inflammatory markers and their association with Alzheimer's disease: A cross-sectional analysis.

Indian J Psychiatry. 2024-3

[5]
Microbiological and Salivary Biomarkers Successfully Predict Site-Specific and Whole-Mouth Outcomes of Nonsurgical Periodontal Treatment.

J Clin Med. 2024-7-21

[6]
Lupeol protect against LPS-induced neuroinflammation and amyloid beta in adult mouse hippocampus.

Front Nutr. 2024-7-10

[7]
Therapeutics for neurodegenerative diseases by targeting the gut microbiome: from bench to bedside.

Transl Neurodegener. 2024-2-27

[8]
Profiles of subgingival microbiomes and gingival crevicular metabolic signatures in patients with amnestic mild cognitive impairment and Alzheimer's disease.

Alzheimers Res Ther. 2024-2-19

[9]
The oral-brain axis: can periodontal pathogens trigger the onset and progression of Alzheimer's disease?

Front Microbiol. 2024-2-1

[10]
Periodontitis and brain magnetic resonance imaging markers of Alzheimer's disease and cognitive aging.

Alzheimers Dement. 2024-3

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

推荐工具

医学文档翻译智能文献检索