Who's who in human recombination: BRCA2 and RAD52.
作者信息
Liu Jie, Heyer Wolf-Dietrich
机构信息
Department of Microbiology, University of California, Davis, CA 95616, USA.
出版信息
Proc Natl Acad Sci U S A. 2011 Jan 11;108(2):441-2. doi: 10.1073/pnas.1016614108. Epub 2010 Dec 28.
Abstract
摘要
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本文引用的文献
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Biochemistry of eukaryotic homologous recombination.真核生物同源重组的生物化学
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Rad52 inactivation is synthetically lethal with BRCA2 deficiency.Rad52 失活与 BRCA2 缺陷具有合成致死性。
Proc Natl Acad Sci U S A. 2011 Jan 11;108(2):686-91. doi: 10.1073/pnas.1010959107. Epub 2010 Dec 8.
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Human BRCA2 protein promotes RAD51 filament formation on RPA-covered single-stranded DNA.人源 BRCA2 蛋白促进 RAD51 丝在 RPA 覆盖的单链 DNA 上形成。
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Purified human BRCA2 stimulates RAD51-mediated recombination.纯化的人源 BRCA2 可刺激 RAD51 介导的重组。
Nature. 2010 Oct 7;467(7316):678-83. doi: 10.1038/nature09399.
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Replication stress induces sister-chromatid bridging at fragile site loci in mitosis.复制应激在有丝分裂过程中诱导脆弱位点处的姐妹染色单体桥接。
Nat Cell Biol. 2009 Jun;11(6):753-60. doi: 10.1038/ncb1882. Epub 2009 May 24.
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DNA repair deficiency as a therapeutic target in cancer.DNA修复缺陷作为癌症的治疗靶点。
Curr Opin Genet Dev. 2008 Feb;18(1):80-6. doi: 10.1016/j.gde.2008.01.016. Epub 2008 Mar 14.
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Resistance to therapy caused by intragenic deletion in BRCA2.由BRCA2基因内缺失导致的治疗耐药性。
Nature. 2008 Feb 28;451(7182):1111-5. doi: 10.1038/nature06548. Epub 2008 Feb 10.
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Secondary mutations as a mechanism of cisplatin resistance in BRCA2-mutated cancers.继发性突变作为BRCA2突变癌症中顺铂耐药的一种机制。
Nature. 2008 Feb 28;451(7182):1116-20. doi: 10.1038/nature06633. Epub 2008 Feb 10.
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Compensatory role for Rad52 during recombinational repair in Ustilago maydis.玉米黑粉菌重组修复过程中Rad52的补偿作用。
Mol Microbiol. 2008 Mar;67(5):1156-68. doi: 10.1111/j.1365-2958.2008.06116.x. Epub 2008 Jan 15.
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DNA binding, annealing, and strand exchange activities of Brh2 protein from Ustilago maydis.玉米黑粉菌Brh2蛋白的DNA结合、退火及链交换活性
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