Department of Genetics and Development, Columbia University Irving Medical Center, New York, NY 10032, USA.
Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY 10032, USA.
Mol Cell. 2016 Dec 15;64(6):1017-1019. doi: 10.1016/j.molcel.2016.11.036.
The role of mammalian RAD52 has been mysterious due to the lack of a strong DNA repair phenotype of RAD52-deficient cells. In this issue of Molecular Cell, studies by Bhowmick et al. (2016) and Sotiriou et al. (2016) reveal an unexpected role for RAD52 in promoting DNA synthesis following replication stress.
由于缺乏 RAD52 缺陷细胞的强烈 DNA 修复表型，哺乳动物 RAD52 的作用一直是个谜。在本期《分子细胞》中，Bhowmick 等人的研究和 Sotiriou 等人的研究揭示了 RAD52 在复制应激后促进 DNA 合成中的一个意想不到的作用。
