使用高效杂多酸催化法合成取代的 1,4-二氮杂卓和 1,5-苯并二氮杂卓。
Synthesis of substituted 1,4-diazepines and 1,5-benzodiazepines using an efficient heteropolyacid-catalyzed procedure.
机构信息
Laboratory of Applied Organic Chemistry, Houari Boumediene University of Sciences and Technology, BP 31, El-Alia, Bab-Ezzouar, 16111 Algiers, Algeria.
出版信息
Molecules. 2010 Dec 28;16(1):92-9. doi: 10.3390/molecules16010092.
Abstract
An efficient and improved procedure for the synthesis of 1,4-diazepine and 1,5-benzodiazepine derivatives via the reaction of ketimine intermediates with aldehydes in the presence of Keggin-type heteropolyacids (HPAs) was developed. High yields and short reaction times were obtained for both electron-releasing and electron-withdrawing substituted 1,4-diazepine and 1,5-benzodiazepines derivatives.
摘要
开发了一种通过酮亚胺中间体与醛在 Keggin 型杂多酸（HPAs）存在下反应合成 1,4-二氮杂环庚烷和 1,5-苯并二氮杂环庚烷衍生物的高效改进方法。对于供电子和吸电子取代的 1,4-二氮杂环庚烷和 1,5-苯并二氮杂环庚烷衍生物，均获得了高产率和短反应时间。
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