弗朗西斯菌的氯消毒。
Chlorine disinfection of Francisella tularensis.
机构信息
Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.
出版信息
Lett Appl Microbiol. 2011 Jan;52(1):84-6. doi: 10.1111/j.1472-765x.2010.02971.x.
AIMS
To determine the range of free available chlorine (FAC) required for disinfection of the live vaccine strain (LVS) and wild-type strains of Francisella tularensis.
METHODS AND RESULTS
Seven strains of planktonic F. tularensis were exposed to 0·5 mg·l(-1) FAC for two pH values, 7 and 8, at 5 and 25°C. LVS was inactivated 2 to 4 times more quickly than any of the wild-type F. tularensis strains at pH 8 and 5°C.
CONCLUSIONS
Free available chlorine residual concentrations routinely maintained in drinking water distribution systems would require up to two hours to reduce all F. tularensis strains by 4 log10. LVS was inactivated most quickly of the tested strains.
SIGNIFICANCE AND IMPACT OF THE STUDY
This work provides contact time (CT) values that are useful for drinking water risk assessment and also suggests that LVS may not be a good surrogate in disinfection studies.
目的
确定用于消毒活疫苗株（LVS）和土拉弗朗西斯菌野生型菌株所需的游离有效氯（FAC）范围。
方法和结果
将 7 株浮游土拉弗朗西斯菌在 5°C 和 25°C 时，暴露于 0.5mg·l(-1) FAC 两种 pH 值（7 和 8）下。在 pH8 和 5°C 时，LVS 的失活速度比任何野生型土拉弗朗西斯菌菌株都快 2 到 4 倍。
结论
在饮用水分配系统中常规保持的游离有效氯残留浓度需要长达 2 小时才能使所有土拉弗朗西斯菌菌株减少 4 个对数。LVS 是测试菌株中失活最快的。
研究的意义和影响
这项工作提供了接触时间（CT）值，这些值可用于饮用水风险评估，也表明 LVS 可能不是消毒研究中的良好替代物。
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