Pani Nibedita, Mishra Shakti Bedanta, Rath Shovan Kumar
Department of Anaesthesiology, SCB Medical College, Cuttack-753 007, India.
Indian J Anaesth. 2010 Sep;54(5):387-93. doi: 10.4103/0019-5049.71028.
Pregnancy induces progressive changes in maternal carbohydrate metabolism. As pregnancy advances insulin resistance and diabetogenic stress due to placental hormones necessitate compensatory increase in insulin secretion. When this compensation is inadequate gestational diabetes develops. 'Gestational diabetes mellitus' (GDM) is defined as carbohydrate intolerance with onset or recognition during pregnancy. Women diagnosed to have GDM are at increased risk of future diabetes predominantly type 2 DM as are their children. Thus GDM offers an important opportunity for the development, testing and implementation of clinical strategies for diabetes prevention. Timely action taken now in screening all pregnant women for glucose intolerance, achieving euglycaemia in them and ensuring adequate nutrition may prevent in all probability, the vicious cycle of transmitting glucose intolerance from one generation to another. Given that diabetic mothers have proportionately larger babies it is likely that vaginal delivery will be more difficult than in the normal population, with a higher rate of instrumentally assisted delivery, episiotomy and conversion to urgent caesarean section. So an indwelling epidural catheter is a better choice for labour analgesia as well to use, should a caesarean delivery become necessary. Diabetes in pregnancy has potential serious adverse effects for both the mother and the neonate. Standardized multidisciplinary care including anaesthetists should be carried out obsessively throughout pregnancy. Diabetes is the most common endocrine disorder of pregnancy. In pregnancy, it has considerable cost and care demands and is associated with increased risks to the health of the mother and the outcome of the pregnancy. However, with careful and appropriate screening, multidisciplinary management and a motivated patient these risks can be minimized.
妊娠会引起母体碳水化合物代谢的渐进性变化。随着妊娠进展,由于胎盘激素导致的胰岛素抵抗和致糖尿病应激需要胰岛素分泌进行代偿性增加。当这种代偿不足时,就会发生妊娠期糖尿病。“妊娠期糖尿病”(GDM)定义为在妊娠期间出现或被识别出的碳水化合物不耐受。被诊断患有GDM的女性及其子女未来患糖尿病(主要是2型糖尿病)的风险会增加。因此,GDM为糖尿病预防临床策略的制定、测试和实施提供了重要契机。现在及时采取行动对所有孕妇进行葡萄糖不耐受筛查,使她们实现血糖正常,并确保充足营养,很可能会预防葡萄糖不耐受代代相传的恶性循环。鉴于糖尿病母亲所生的婴儿相对较大,阴道分娩可能比正常人群更困难,器械助产、会阴切开术和紧急剖宫产的发生率更高。因此,留置硬膜外导管是分娩镇痛的更好选择,并且如果需要进行剖宫产也可使用。妊娠糖尿病对母亲和新生儿都有潜在的严重不良影响。在整个妊娠期间应严格开展包括麻醉医生在内的标准化多学科护理。糖尿病是妊娠最常见的内分泌疾病。在妊娠期间,它有相当大的成本和护理需求,并且与母亲健康风险增加和妊娠结局不良相关。然而,通过仔细且适当的筛查、多学科管理以及积极配合的患者,这些风险可以降至最低。