黄荆抗炎解热作用的筛选
Screening of anti-inflammatory and antipyretic activity of Vitex leucoxylon Linn.
机构信息
Pranveer Singh Institute of Technology, Kanpur, India.
出版信息
Indian J Pharmacol. 2010 Dec;42(6):409-11. doi: 10.4103/0253-7613.71891.
OBJECTIVE
This study was designed to evaluate the anti-inflammatory and antipyretic activity of ethyl acetate extract of Vitex leucoxylon Linn. in various animal experimental models.
MATERIALS AND METHODS
Ethyl acetate extract of V. leucoxylon Linn. evaluated for anti-inflammatory activity in carrageenan, mediator-induced rat paw edema, and cotton pellet-induced granuloma model. The antipyretic activity was evaluated by yeast-induced pyrexia model.
RESULTS
Single administration of the ethyl acetate extract of V. leucoxylon Linn. at dose of 500 mg/kg p.o. showed significant (P < 0.001) inhibition of rat paw edema. The ethyl acetate extract showed significant antipyretic activity in brewer yeast-induced pyrexia in rats throughout the observation period of 4 h.
CONCLUSION
This study shows that ethyl acetate extract of V. leucoxylon Linn. has significant anti-inflammatory and antipyretic activity.
目的
本研究旨在评估牡荆素乙酸乙酯提取物在各种动物实验模型中的抗炎和解热活性。
材料与方法
采用角叉菜胶、介质诱导的大鼠爪肿胀和棉垫诱导的肉芽肿模型评价牡荆素乙酸乙酯提取物的抗炎活性。采用酵母诱导发热模型评价其解热活性。
结果
牡荆素乙酸乙酯提取物单次给药 500mg/kg po 显著抑制大鼠爪肿胀（P<0.001）。在整个 4 小时的观察期内，牡荆素乙酸乙酯提取物对酵母诱导发热的大鼠均表现出显著的解热活性。
结论
本研究表明，牡荆素乙酸乙酯提取物具有显著的抗炎和解热活性。
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