吲哚美辛的退热作用。
The antipyretic effect of indomethacin.
作者信息
Clark W G, Cumby H R
出版信息
J Physiol. 1975 Jul;248(3):625-38. doi: 10.1113/jphysiol.1975.sp010992.
Abstract
- Several possible mechanisms of the antipyretic action of indomethacin administered cat. 2. Indomethacin did not decrease bacterial endotoxin-induced release of endogenous pyrogen in vivo. 3. Indomethacin (5-40 mug/kg) inhibited the pyrogenic effect of peripherally or centrally administered leucocytic progen. A dose of 10 mug/kg caused a parallel shift to the right of the log dose-response curve for I.V. leucocytic pyrogen and reduced the potency of the pyrogen at least 50%. 4. Incubation of leucocytic pyrogen with indomethacin did not alter its pyrogenic potency. 5. Indomethacin exerted only a slight non-dose-related hypothermic effect in afebrile animals. 6. Indomethacin (up to 1 mg/kg) did not diminish the hyperthermic response to intraventricular administration of prostaglandin E1. 7. This pattern of activity indicates that indomethacin acts centrally to inhibit an effect of leucocytic pyrogen.
摘要
- 给猫注射消炎痛的解热作用的几种可能机制。2. 消炎痛在体内并未降低细菌内毒素诱导的内源性致热原的释放。3. 消炎痛（5 - 40微克/千克）抑制外周或中枢给予白细胞致热原的致热作用。10微克/千克的剂量使静脉注射白细胞致热原的对数剂量反应曲线平行右移，并使致热原的效力至少降低50%。4. 白细胞致热原与消炎痛孵育并未改变其致热效力。5. 消炎痛在无热动物中仅产生轻微的与剂量无关的体温降低作用。6. 消炎痛（高达1毫克/千克）并未减弱对脑室内给予前列腺素E1的发热反应。7. 这种活性模式表明消炎痛在中枢起作用以抑制白细胞致热原的一种作用。
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