Sundaram Medical Foundation, Dr. Rangarajan Memorial Hospital, Shanthi Colony, IV Avenue Annanagar, Chennai 600 040, India.
Indian J Pharmacol. 2010 Dec;42(6):412-5. doi: 10.4103/0253-7613.71894.
Paracetamol (acetaminophen), though considered a safe, "over the counter" analgesic and antipyretic, can cause liver injury with overdose. Therapeutic misadventure is a unique problem where the existing nomogram used for acute poisoning is not applicable. In this context, early initiation of N-acetylcysteine even before a biochemical evidence of liver injury may be beneficial. A series of 6 children with this type of paracetamol overdose are presented here to increase the awareness and understanding of this problem since no such data is available from India.
对乙酰氨基酚（扑热息痛），尽管被认为是一种安全的“非处方”镇痛药和解热药，但过量使用也会导致肝损伤。治疗失误是一个独特的问题，现有的用于急性中毒的剂量表在此情况下并不适用。在这种情况下，即使在生化证据显示肝损伤之前，早期开始使用 N-乙酰半胱氨酸可能是有益的。本文介绍了一组 6 例此类扑热息痛过量的儿童病例，旨在提高对这一问题的认识和理解，因为印度尚无此类数据。
