Joung Kyoung Hwa, Cho Soo Chul
Department of Nursing, Honam University, Gwangju, Korea.
Korean J Pediatr. 2010 Aug;53(8):790-4. doi: 10.3345/kjp.2010.53.8.790. Epub 2010 Aug 31.
The purpose of this study was to test the efficacy of treating the pain among newborn infants associated with a medical procedure with sucrose with regard to overall physiological and behavioral stability.
103 newborn infants were enrolled in this study. The control group (n=63) did not receive any treatment. The experimental group (n=40) received 2 mL of 24% sucrose solution two minutes before a routine heel stick. The pain was assessed by measurements of physiological changes [e.g. pulse rate, oxygen saturation, salivary cortisol (hydrocortisone)] and behavioral changes [e.g. crying time, and the neonatal infant pain scale (NIPS) for neonates].
There were no differences among the groups with respect to physiological changes associated with the pain from the procedure. However, there were significant group differences in behavioral changes to the pain. In the control group, the median crying time was 13 seconds, while in the experimental group, the median crying time was 3.5 seconds (P=.000). In the control group the median NIPS score was 4, while in the experimental group the median NIPS score was 2 (P=.000).
These findings suggest that sucrose can be an effective method for the management of stress responses in infants with regard to behavior. However, this treatment had no significant physiological effects.
本研究旨在测试蔗糖对接受医疗程序的新生儿疼痛的治疗效果，以及其对整体生理和行为稳定性的影响。
103名新生儿参与了本研究。对照组（n = 63）未接受任何治疗。实验组（n = 40）在常规足跟采血前两分钟接受2 mL 24%的蔗糖溶液。通过测量生理变化[如脉搏率、血氧饱和度、唾液皮质醇（氢化可的松）]和行为变化[如哭闹时间，以及新生儿疼痛量表（NIPS）]来评估疼痛。
在与医疗程序相关的疼痛引起的生理变化方面，各组之间没有差异。然而，在对疼痛的行为变化方面，各组之间存在显著差异。对照组的哭闹时间中位数为13秒，而实验组的哭闹时间中位数为3.5秒（P = .000）。对照组的NIPS评分中位数为4，而实验组的NIPS评分中位数为2（P = .000）。
这些发现表明，蔗糖对于管理婴儿行为方面的应激反应可能是一种有效的方法。然而，这种治疗对生理没有显著影响。
