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CDH3/原钙黏蛋白3调节人胆管癌细胞HuCCT1的迁移。

CDH3/P-Cadherin regulates migration of HuCCT1 cholangiocarcinoma cells.

作者信息

Baek Sungmin, Lee Yong-Whan, Yoon Sik, Baek Sun-Yong, Kim Bong-Seon, Oh Sae-Ock

机构信息

Department of Anatomy, School of Medicine, Pusan National University, Yangsan, Korea.

出版信息

Anat Cell Biol. 2010 Jun;43(2):110-7. doi: 10.5115/acb.2010.43.2.110. Epub 2010 Jun 30.

DOI:10.5115/acb.2010.43.2.110
PMID:21189991
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2998785/
Abstract

Intrahepatic cholangiocarcinoma is the second most common subtype of primary hepatobilliary cancer. Despite advances in surgical and medical therapy, its survival rate remains poor. Compared to hepatocellular carcinoma (HCC), the most common liver malignancy, the underlying mechanisms of cholangiocarcinoma carcinogenesis are poorly characterized. P-cadherin (CDH3) is a cadherin super family member. Although CDH3 is frequently over-expressed in cholangiocarcinoma tissues, its roles have never been characterized. To determine the roles of CDH3 in cholangiocarcinoma, we investigated CDH3 function in HuCCT1 cells using specific siRNA. Transfection with CDH3 siRNA did not affect proliferation of HuCCT1 cells. However, cell migration and invasion were significantly reduced when CDH3 was down-regulated. In addition, expressions of several biomarkers for epithelial-mesenchymal transition (EMT) were not changed by CDH3 down-regulation. These results suggest that CDH3 regulates cell migration independent of EMT in cholangiocarcinoma cells.

摘要

肝内胆管癌是原发性肝胆癌的第二常见亚型。尽管手术和药物治疗取得了进展，但其生存率仍然很低。与最常见的肝脏恶性肿瘤肝细胞癌（HCC）相比，胆管癌发生的潜在机制仍不清楚。P-钙黏蛋白（CDH3）是钙黏蛋白超家族成员。虽然CDH3在胆管癌组织中经常过度表达，但其作用从未被阐明。为了确定CDH3在胆管癌中的作用，我们使用特异性siRNA研究了其在HuCCT1细胞中的功能。用CDH3 siRNA转染不影响HuCCT1细胞的增殖。然而，当CDH3下调时，细胞迁移和侵袭显著减少。此外，几种上皮-间质转化（EMT）生物标志物的表达不受CDH3下调的影响。这些结果表明，CDH3在胆管癌细胞中独立于EMT调节细胞迁移。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4dd4/2998785/5935fe0292f6/acb-43-110-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4dd4/2998785/84c3e4bffe1d/acb-43-110-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4dd4/2998785/f5d6574e435c/acb-43-110-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4dd4/2998785/633ed939752e/acb-43-110-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4dd4/2998785/f34dbfac1be0/acb-43-110-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4dd4/2998785/5935fe0292f6/acb-43-110-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4dd4/2998785/84c3e4bffe1d/acb-43-110-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4dd4/2998785/f5d6574e435c/acb-43-110-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4dd4/2998785/633ed939752e/acb-43-110-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4dd4/2998785/f34dbfac1be0/acb-43-110-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4dd4/2998785/5935fe0292f6/acb-43-110-g005.jpg

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