Department of Chemistry, Wuhan University, Luojia Hill, Wuhan 430072, China.
Colloids Surf B Biointerfaces. 2011 Apr 1;83(2):313-20. doi: 10.1016/j.colsurfb.2010.11.039. Epub 2010 Dec 7.
Novel amphiphilic cationic cellulose (HMQC) derivatives carrying long chain alkyl groups as hydrophobic moieties and quaternary ammonium groups as hydrophilic moieties were synthesized. Structure and properties of the amphiphilic cellulose derivatives were characterized by elemental analysis, FT-IR, (1)H NMR, ζ-potential measurement, dynamic light scattering (DLS), fluorescence spectroscopy and transmission electron microscopy (TEM). The results revealed that HMQCs can be self-assembled into cationic micelles in distilled water with the average hydrodynamic radius of 320-430 nm. The cytotoxicity study showed that the HMQC exhibited low cytotoxicity. Prednisone acetate, a water insoluble anti-inflammation drug, was chosen as a model drug to investigate the utilization of self-assembled HMQC micelles as a delivery carrier for poorly water-soluble drugs. The study indicated that the prednisone acetate could be incorporated effectively in the self-assembled HMQC micelles and be controlled released.
合成了新型两亲性阳离子纤维素（HMQC）衍生物，其作为疏水部分带有长链烷基，作为亲水部分带有季铵基团。通过元素分析、傅里叶变换红外光谱（FT-IR）、（1）H 核磁共振、ζ-电位测量、动态光散射（DLS）、荧光光谱和透射电子显微镜（TEM）对两亲性纤维素衍生物的结构和性能进行了表征。结果表明，HMQC 可以在蒸馏水中自组装成阳离子胶束，平均水动力半径为 320-430nm。细胞毒性研究表明，HMQC 表现出低细胞毒性。醋酸泼尼松龙，一种不溶于水的抗炎药物，被选为模型药物，以研究自组装 HMQC 胶束作为难溶于水的药物的递送载体的应用。研究表明，醋酸泼尼松龙可以有效地掺入自组装的 HMQC 胶束中，并进行控制释放。
