Nagaoka S, Miyazaki H, Aoyama Y, Yoshida A
Department of Agricultural Chemistry, Nagoya University, Japan.
Br J Nutr. 1990 Jul;64(1):161-9. doi: 10.1079/bjn19900018.
Dietary polychlorinated biphenyls (PCBs) caused hypercholesterolaemia in rats. The concentration and output of biliary cholesterol was significantly lower than that of the control group. Biliary output of total bile acids was significantly decreased in rats given the PCB-supplemented diet. Faecal excretion of total steroids (sum of neutral steroids and acidic steroids) was not significantly changed in rats given the PCB-supplemented diet. The present results indicate that dietary PCBs cause hypercholesterolaemia without modifying the faecal total steroids excretion. These results suggest that PCBs produce hypercholesterolaemia accompanied by changes in biliary or faecal excretion of bile acids and neutral steroids in addition to an increase in hepatic cholesterol synthesis.
膳食中的多氯联苯（PCBs）可导致大鼠出现高胆固醇血症。胆汁中胆固醇的浓度和排出量显著低于对照组。给予补充多氯联苯饮食的大鼠胆汁中总胆汁酸的排出量显著降低。给予补充多氯联苯饮食的大鼠粪便中总类固醇（中性类固醇和酸性类固醇之和）的排泄量没有显著变化。目前的结果表明，膳食中的多氯联苯导致高胆固醇血症，但不改变粪便中总类固醇的排泄。这些结果表明，多氯联苯除了增加肝脏胆固醇合成外，还会导致高胆固醇血症，并伴有胆汁酸和中性类固醇的胆汁或粪便排泄变化。
