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大鼠饮食中酪氨酸过量或多氯联苯诱导的高胆固醇血症的比较研究。

Comparative studies on the hypercholesterolaemia induced by excess dietary tyrosine or polychlorinated biphenyls in rats.

作者信息

Nagaoka S, Kato M, Aoyama Y, Yoshida A

机构信息

Department of Agricultural Chemistry, Nagoya University, Japan.

出版信息

Br J Nutr. 1986 Sep;56(2):509-17. doi: 10.1079/bjn19860130.

DOI:10.1079/bjn19860130
PMID:2890372
Abstract
  1. The effects of dietary polychlorinated biphenyls (PCB) and excess tyrosine on serum and liver lipids, urinary ascorbic acid and catecholamines were compared in male Wistar rats. 2. Serum levels of cholesterol, urinary ascorbic acid, norepinephrine, epinephrine, dopamine and histamine were significantly increased in rats given either PCB or excess tyrosine. 3. The hypercholesterolaemia induced by PCB or excess tyrosine was blocked by the adrenergic alpha-blocker, phenoxybenzamine. 4. The present results suggest causal interrelations between the hypercholesterolaemia induced by dietary PCB or excess tyrosine and the secretion of catecholamines.
摘要
  1. 在雄性Wistar大鼠中比较了膳食多氯联苯(PCB)和过量酪氨酸对血清和肝脏脂质、尿中抗坏血酸和儿茶酚胺的影响。2. 给予PCB或过量酪氨酸的大鼠血清胆固醇水平、尿中抗坏血酸、去甲肾上腺素、肾上腺素、多巴胺和组胺显著升高。3. PCB或过量酪氨酸诱导的高胆固醇血症被肾上腺素能α受体阻滞剂酚苄明阻断。4. 目前的结果表明膳食PCB或过量酪氨酸诱导的高胆固醇血症与儿茶酚胺分泌之间存在因果关系。

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Comparative studies on the hypercholesterolaemia induced by excess dietary tyrosine or polychlorinated biphenyls in rats.大鼠饮食中酪氨酸过量或多氯联苯诱导的高胆固醇血症的比较研究。
Br J Nutr. 1986 Sep;56(2):509-17. doi: 10.1079/bjn19860130.
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Effects of dietary polychlorinated biphenyls on cholesterol catabolism in rats.膳食多氯联苯对大鼠胆固醇分解代谢的影响。
Br J Nutr. 1990 Jul;64(1):161-9. doi: 10.1079/bjn19900018.
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Effect of polychlorinated biphenyls on lipids and ascorbic acid metabolism in streptozotocin-induced diabetic rats.多氯联苯对链脲佐菌素诱导的糖尿病大鼠脂质和抗坏血酸代谢的影响。
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Long-term effects of dietary polychlorinated biphenyl and high level of vitamin E on ascorbic acid and lipid metabolism in rats.
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Effect of methionine and threonine on the hypercholesterolemia induced by polychlorinated biphenyls in rats fed a nonprotein diet.
J Nutr Sci Vitaminol (Tokyo). 1989 Dec;35(6):589-96. doi: 10.3177/jnsv.35.589.
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Ameliorative effect of dietary probucol on polychlorinated biphenyls-induced hypercholesterolemia and lipid peroxidation in the rat.
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Effects of dietary methionine, cystine and potassium sulfate on serum cholesterol and urinary ascorbic acid in rats fed PCB.膳食蛋氨酸、胱氨酸和硫酸钾对喂食多氯联苯的大鼠血清胆固醇和尿中抗坏血酸的影响。
J Nutr. 1986 Sep;116(9):1660-6. doi: 10.1093/jn/116.9.1660.
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Effect of dietary polychlorinated biphenyls (PCB) for increasing urinary ascorbic acid and plasma cholesterol levels in rats.膳食多氯联苯(PCB)对提高大鼠尿中抗坏血酸水平和血浆胆固醇水平的影响。
J Nutr Sci Vitaminol (Tokyo). 1980;26(6):629-32. doi: 10.3177/jnsv.26.629.
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Effects of excess dietary tyrosine on cholesterol, bile acid metabolism and mixed-function oxidase system in rats.过量膳食酪氨酸对大鼠胆固醇、胆汁酸代谢及混合功能氧化酶系统的影响。
J Nutr. 1990 Oct;120(10):1134-9. doi: 10.1093/jn/120.10.1134.

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