大鼠饮食中酪氨酸过量或多氯联苯诱导的高胆固醇血症的比较研究。

Comparative studies on the hypercholesterolaemia induced by excess dietary tyrosine or polychlorinated biphenyls in rats.

Nagaoka S, Kato M, Aoyama Y, Yoshida A

Department of Agricultural Chemistry, Nagoya University, Japan.

Br J Nutr. 1986 Sep;56(2):509-17. doi: 10.1079/bjn19860130.

Abstract

The effects of dietary polychlorinated biphenyls (PCB) and excess tyrosine on serum and liver lipids, urinary ascorbic acid and catecholamines were compared in male Wistar rats. 2. Serum levels of cholesterol, urinary ascorbic acid, norepinephrine, epinephrine, dopamine and histamine were significantly increased in rats given either PCB or excess tyrosine. 3. The hypercholesterolaemia induced by PCB or excess tyrosine was blocked by the adrenergic alpha-blocker, phenoxybenzamine. 4. The present results suggest causal interrelations between the hypercholesterolaemia induced by dietary PCB or excess tyrosine and the secretion of catecholamines.

摘要

在雄性Wistar大鼠中比较了膳食多氯联苯（PCB）和过量酪氨酸对血清和肝脏脂质、尿中抗坏血酸和儿茶酚胺的影响。2. 给予PCB或过量酪氨酸的大鼠血清胆固醇水平、尿中抗坏血酸、去甲肾上腺素、肾上腺素、多巴胺和组胺显著升高。3. PCB或过量酪氨酸诱导的高胆固醇血症被肾上腺素能α受体阻滞剂酚苄明阻断。4. 目前的结果表明膳食PCB或过量酪氨酸诱导的高胆固醇血症与儿茶酚胺分泌之间存在因果关系。