Division of Metabolic Diseases, Center for Biomedical Sciences, National Institute of Health, 194 Tongillo, Eunpyeong-gu, Seoul 122-701, Republic of Korea.
Nutr Metab Cardiovasc Dis. 2012 Mar;22(3):260-8. doi: 10.1016/j.numecd.2010.08.010. Epub 2010 Dec 28.
Leptin is an important regulator of energy metabolism. It is considered to be positively related to body adiposity and metabolic disorders in obese adults and children. The purpose of this study was to evaluate the relationship between baseline circulating leptin, insulin and adiponectin levels and future overweight and metabolic risks in a paediatric population-based cohort.
First-grade students, who entered elementary school at age 7 years in Gwacheon, a Korean city, were enrolled in this cohort study, and followed from 1st grade to 5th grade. Annual physical examinations from 2005 to 2009 were performed. In 2006, the levels of serum glucose, insulin, leptin and adiponectin and lipid profiles were examined. In 2008, the above parameters, except for adiponectin, were measured again in 381 children (202 boys and 179 girls) who participated. In 2006, 10.2% of the children were overweight (body mass index (BMI) ≥ 85th percentile), and after 2 years, an additional 3% became overweight. Compared with insulin and adiponectin, leptin was most highly associated with current and future BMI, and percent body fat. Boys in the highest tertile for initial leptin (T3) showed the highest prevalence of overweight and metabolic risk scores among three leptin tertile groups. Girls showed the same trends as boys. High initial leptin levels could be predictive of greater future BMI and metabolic risk score (p < 0.001).
These results suggest that elevated serum leptin concentrations among the childhood population could be a marker for future BMI and metabolic disorders.
瘦素是能量代谢的重要调节剂。它被认为与肥胖成年人和儿童的体脂和代谢紊乱呈正相关。本研究的目的是评估儿童人群中基线循环瘦素、胰岛素和脂联素水平与未来超重和代谢风险之间的关系。
本队列研究纳入了韩国果川市入读小学一年级（7 岁）的学生，并从一年级随访至五年级。2005 年至 2009 年每年进行一次体格检查。2006 年检测了血清葡萄糖、胰岛素、瘦素和脂联素水平及血脂谱。2008 年，在 381 名（202 名男孩和 179 名女孩）参与的儿童中再次测量了上述参数，除脂联素外。2006 年，10.2%的儿童超重（体重指数（BMI）≥第 85 百分位），2 年后又有 3%的儿童超重。与胰岛素和脂联素相比，瘦素与当前和未来的 BMI 和体脂百分比最相关。初始瘦素（T3）最高三分位组的男孩超重和代谢风险评分最高，高于其他两个瘦素三分位组。女孩的趋势与男孩相同。较高的初始瘦素水平可能预示着未来 BMI 和代谢风险评分的增加（p<0.001）。
这些结果表明，儿童人群中血清瘦素浓度升高可能是未来 BMI 和代谢紊乱的标志物。
