Department of Family Medicine, College of Medicine, Korea University, Seoul 136-713, South Korea.
Endocr J. 2013;60(5):609-16. doi: 10.1507/endocrj.ej12-0384. Epub 2013 Jan 12.
Adipokines are associated with obesity. However, the relationships between adipokines, specifically vaspin, obesity, and obesity-related variables remain controversial, and only a few studies have been conducted which examines them in children. We investigated the relationships between obesity in prepubertal Korean children and three types of adipokines: vaspin, leptin, and visfatin. In this cross-sectional study, 168 nine-year-old boys and 176 nine-year-old girls participated in a school-based health examination program. Children were classified as overweight using the Korean Pediatric Society 2007 guidelines. Overweight boys and girls had higher leptin and vaspin levels than both boys and girls of normal weight, whereas only overweight boys had higher visfatin levels than normal weight boys. Leptin, visfatin and vaspin concentrations were correlated with obesity-related variables. A multiple logistic regression analysis showed that systolic blood pressure (SBP), total cholesterol (TC), alanine aminotransferase (ALT), homeostasis model assessment of insulin resistance (HOMA-IR), leptin, and vaspin were associated with an increased risk of being overweight, whereas high-density lipoprotein (HDL) cholesterol was associated with a decreased risk of being overweight. Elevated vaspin and leptin levels are associated with obesity in prepubertal Korean children.
脂联素与肥胖有关。然而，脂联素（尤其是 vaspin）、肥胖与肥胖相关变量之间的关系仍存在争议，只有少数研究对儿童进行了相关研究。我们调查了三种脂联素（vaspin、瘦素和内脂素）与韩国青春期前儿童肥胖之间的关系。在这项横断面研究中，168 名 9 岁男孩和 176 名 9 岁女孩参加了学校健康检查计划。根据韩国儿科学会 2007 年指南，将超重儿童分类。超重男孩和女孩的瘦素和 vaspin 水平高于正常体重男孩和女孩，而只有超重男孩的内脂素水平高于正常体重男孩。瘦素、内脂素和 vaspin 浓度与肥胖相关变量相关。多元逻辑回归分析显示，收缩压（SBP）、总胆固醇（TC）、丙氨酸氨基转移酶（ALT）、胰岛素抵抗评估的稳态模型（HOMA-IR）、瘦素和 vaspin 与超重风险增加相关，而高密度脂蛋白（HDL）胆固醇与超重风险降低相关。青春期前韩国儿童肥胖与 vaspin 和瘦素水平升高有关。
