Inhibition of growth of Chlamydia trachomatis by tumor necrosis factor is accompanied by increased prostaglandin synthesis.
作者信息
Holtmann H, Shemer-Avni Y, Wessel K, Sarov I, Wallach D
机构信息
Department of Pharmacology and Toxicology, Medical School, Hannover, Federal Republic of Germany.
出版信息
Infect Immun. 1990 Oct;58(10):3168-72. doi: 10.1128/iai.58.10.3168-3172.1990.
Abstract
Development of Chlamydia trachomatis (L2/434/Bu) in HEp-2 cells was inhibited by treatment of the cells with recombinant human alpha tumor necrosis factor (TNF). In the infected cultures that were treated with TNF, high concentrations of prostaglandin E2(PGE2) were detected, exceeding by far the concentrations found in TNF-treated but uninfected cells or in infected cells that were not treated with TNF. PGE2 levels increased gradually for 2 days after infection. Raising the tryptophan concentration in the culture medium, which reversed the inhibition of chlamydial replication by TNF, also blocked the increase in PGE2 formation. However, neutralizing antibodies to beta interferon, which also interfered with the antichlamydial effect of TNF, did not decrease PGE2 formation. Excessive formation of PGE2 by cells infected with chlamydiae and treated by TNF might be related to some of the complications associated with chlamydial infection.
摘要
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本文引用的文献
1
Chlamydial infection in the aetiology of arthritis.
Br Med Bull. 1983 Apr;39(2):168-74. doi: 10.1093/oxfordjournals.bmb.a071811.
2
Control mechanisms governing the infectivity of Chlamydia trachomatis for hela cells: modulation by cyclic nucleotides, prostaglandins and calcium.
J Gen Microbiol. 1982 Mar;128(3):639-50. doi: 10.1099/00221287-128-3-639.
3
Recent advances in Chlamydia trachomatis.
Eur J Epidemiol. 1985 Dec;1(4):235-56. doi: 10.1007/BF00237099.
4
Shock and tissue injury induced by recombinant human cachectin.
Science. 1986 Oct 24;234(4775):470-4. doi: 10.1126/science.3764421.
5
Possible roles of tumor necrosis factor in the pathology of malaria.
Am J Pathol. 1987 Oct;129(1):192-9.
6
Growing tumors induce hypersensitivity to endotoxin and tumor necrosis factor.
Infect Immun. 1987 Sep;55(9):2230-3. doi: 10.1128/iai.55.9.2230-2233.1987.
7
Synergy between tumor necrosis factor and bacterial products causes hemorrhagic necrosis and lethal shock in normal mice.
Proc Natl Acad Sci U S A. 1988 Jan;85(2):607-11. doi: 10.1073/pnas.85.2.607.
8
Inhibition of Chlamydia trachomatis growth by recombinant tumor necrosis factor.
Infect Immun. 1988 Sep;56(9):2503-6. doi: 10.1128/iai.56.9.2503-2506.1988.
9
Tumor necrosis factor/cachectin is an effector of skin and gut lesions of the acute phase of graft-vs.-host disease.
J Exp Med. 1987 Nov 1;166(5):1280-9. doi: 10.1084/jem.166.5.1280.
10
Inhibition of Chlamydia trachomatis replication in HEp-2 cells by human monocyte-derived macrophages.
Infect Immun. 1988 Dec;56(12):3280-4. doi: 10.1128/iai.56.12.3280-3284.1988.
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