脑桥被盖核作为深部脑刺激的靶点。
The pedunculopontine nucleus as a target for deep brain stimulation.
机构信息
Division of Neurosurgery, Department of Surgery, Toronto Western Hospital, University Health Network, University of Toronto, 399 Bathurst Street WW 4-447, Toronto, ON, M5T2S8, Canada.
出版信息
J Neural Transm (Vienna). 2011 Oct;118(10):1461-8. doi: 10.1007/s00702-010-0547-8. Epub 2010 Dec 31.
The pedunculopontine nucleus (PPN) is a brain stem locomotive center that is also involved in the processing of sensory and behavioral information. The PPN has been recently proposed as a potential target for the treatment of axial symptoms in Parkinson's disease (PD). To date, results of the first series of PD patients treated with PPN deep brain stimulation (DBS) have shown promising results. In this article, we review some of the basic aspects of the PPN as a target and the outcome of the recently published clinical trials.
被盖脚桥核（PPN）是脑于运动中枢，也参与感觉和行为信息的处理。PPN 最近被提议作为治疗帕金森病（PD）中轴症状的潜在靶点。迄今为止，接受 PPN 脑深部电刺激（DBS）治疗的第一批 PD 患者的系列结果显示出有希望的结果。在本文中，我们回顾了 PPN 作为靶点的一些基本方面以及最近发表的临床试验结果。
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