Sleep Disorders Unit, Institut National de la Santé et de la Recherche Médicale (INSERM) UMR_975 (Mixed Unity of Research), Pitié-Salpêtrière Hospital, Assistance Publique-Hopitaux de Paris, Paris 6 University, Paris, France.
Ann Neurol. 2010 Apr;67(4):546-9. doi: 10.1002/ana.21912.
The pedunculopontine nucleus is part of the reticular ascending arousal system and is involved in locomotion and sleep. Two patients with Parkinson disease received electrodes that stimulated the pedunculopontine nucleus area to alleviate their severe gait impairment. Instead, we found that low-frequency stimulation of the pedunculopontine nucleus area increased alertness, whereas high-frequency stimulation induced non-rapid eye movement sleep. In addition, the sudden withdrawal of the low-frequency stimulation was consistently followed by rapid eye movement sleep episodes in 1 patient. These data have the potential to benefit patients who suffer from sleep disorders.
脑脚被盖核是网状上行激醒系统的一部分，参与运动和睡眠。两名帕金森病患者接受了刺激脑脚被盖核区域的电极治疗，以缓解严重的步态障碍。然而，我们发现低频刺激脑脚被盖核区域增加了警觉性，而高频刺激则诱导了非快速眼动睡眠。此外，在 1 名患者中，低频刺激的突然停止后总是伴随着快速眼动睡眠期的出现。这些数据有可能使患有睡眠障碍的患者受益。
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