Naito H, Takemura K, Hori A, Yamamoto T, Nakai T, Yasuhara M
Department of Physiology, Kansai Medical University, Osaka, Japan.
Nihon Seirigaku Zasshi. 1990;52(7):229-37.
EEG topography by a microcomputer system (ATAC-3700 Nihon-Kohden) was performed in the rabbit in order to investigate the mechanism of TRH action on the brain wave. Power spectral analysis was carried out using a fast Fourier transform algorithm. The square root of the power spectra was defined as the equivalent potential over each frequency band by Ueno & Matsuoka's method. Potential fields of EEG frequency band were printed out on the topographic maps. The potentials of the electrocortical delta and theta waves were high, while the potentials of the alpha, beta 1 and beta 2 waves were low. Stimulation of the nucleus ventralis anterior (VA) by 3 Hz and 8 Hz resulted in a decrease in these potentials, especially, those of the alpha, beta 1 and beta 2 waves. The potentials of the alpha and fast waves were increased following unilateral destruction of VA. In the rabbit, in which TRH 0.5 mg/kg had been administered beforehand, there was no decrease in the potential of each wave induced by stimulation of VA with frequencies of 3 Hz and 8 Hz. The findings suggest involvement of the diffuse thalamocortical projection system in the activation of EEG by TRH.
为了研究促甲状腺激素释放激素（TRH）对脑电波的作用机制，利用微型计算机系统（日本光电ATAC - 3700）对家兔进行了脑电图地形图检查。采用快速傅里叶变换算法进行功率谱分析。根据上野和松冈的方法，将功率谱的平方根定义为每个频带上的等效电位。脑电图频段的电位场打印在地形图上。皮层电图的δ波和θ波电位较高，而α波、β1波和β2波电位较低。以3Hz和8Hz频率刺激腹前核（VA）会导致这些电位降低，尤其是α波、β1波和β2波的电位。单侧损毁VA后，α波和快波的电位升高。在预先给予0.5mg/kg TRH的家兔中，以3Hz和8Hz频率刺激VA所诱导的各波电位没有降低。这些结果表明，弥散性丘脑皮质投射系统参与了TRH对脑电图的激活作用。
