Departamento de Genética Molecular, Instituto de Fisiología Celular, Circuito Exterior s/n, Ciudad Universitaria, Universidad Nacional Autónoma de México, Mexico D.F. 04510, Mexico.
Biol Chem. 2011 Jan;392(1-2):13-9. doi: 10.1515/BC.2011.013.
Members of the YidC/Oxa1/Alb3 protein family facilitate the insertion, folding and assembly of proteins of the inner membranes of bacteria and mitochondria and the thylakoid membrane of plastids. All homologs share a conserved hydrophobic core region comprising five transmembrane domains. On the basis of phylogenetic analyses, six subgroups of the family can be distinguished which presumably arose from three independent gene duplications followed by functional specialization. During evolution of bacteria, mitochondria and chloroplasts, subgroup-specific regions were added to the core domain to facilitate the association with ribosomes or other components contributing to the substrate spectrum of YidC/Oxa1/Alb3 proteins.
YidC/Oxa1/Alb3 蛋白家族的成员有助于细菌和线粒体的内膜以及质体的类囊体膜中的蛋白质的插入、折叠和组装。所有同源物都具有保守的疏水区核心区域，包含五个跨膜结构域。基于系统发育分析，可以区分该家族的六个亚组，这些亚组可能是由三个独立的基因复制产生的，随后发生了功能特化。在细菌、线粒体和叶绿体的进化过程中，核心结构域中添加了亚组特异性区域，以促进与核糖体或其他有助于 YidC/Oxa1/Alb3 蛋白底物谱的成分的结合。
