Yi Liang, Dalbey Ross E
Department of Chemistry, The Ohio State University, Columbus, Ohio 43210, USA.
Mol Membr Biol. 2005 Jan-Apr;22(1-2):101-11. doi: 10.1080/09687860500041718.
Recent studies have shown that there is a pathway that is evolutionarily conserved for the insertion of proteins into the membrane in mitochondria, chloroplasts, and bacteria. In this pathway, the Oxa1/Alb3/YidC proteins are believed to function as membrane insertases that play an important role in the membrane protein biogenesis of respiratory and energy transduction proteins. Additional roles of the Oxa1/Alb3/YidC members may be in the lateral integration of proteins into the lipid bilayer, and in the folding and assembly of proteins into membrane protein complexes.
最近的研究表明，在线粒体、叶绿体和细菌中，存在一条在进化上保守的将蛋白质插入膜内的途径。在这条途径中，Oxa1/Alb3/YidC蛋白被认为作为膜插入酶发挥作用，在呼吸和能量转导蛋白的膜蛋白生物合成中起重要作用。Oxa1/Alb3/YidC成员的其他作用可能在于蛋白质向脂质双层的侧向整合，以及蛋白质折叠并组装成膜蛋白复合物。
