Hennon Seth W, Soman Raunak, Zhu Lu, Dalbey Ross E
From the Department of Chemistry and Biochemistry, The Ohio State University, Columbus, Ohio 43210.
From the Department of Chemistry and Biochemistry, The Ohio State University, Columbus, Ohio 43210
J Biol Chem. 2015 Jun 12;290(24):14866-74. doi: 10.1074/jbc.R115.638171. Epub 2015 May 6.
The YidC/Alb3/Oxa1 family functions in the insertion and folding of proteins in the bacterial cytoplasmic membrane, the chloroplast thylakoid membrane, and the mitochondrial inner membrane. All members share a conserved region composed of five transmembrane regions. These proteins mediate membrane insertion of an assorted group of proteins, ranging from respiratory subunits in the mitochondria and light-harvesting chlorophyll-binding proteins in chloroplasts to ATP synthase subunits in bacteria. This review discusses the YidC/Alb3/Oxa1 protein family as well as their function in membrane insertion and two new structures of the bacterial YidC, which suggest a mechanism for membrane insertion by this family of insertases.
YidC/Alb3/Oxa1家族在细菌细胞质膜、叶绿体类囊体膜和线粒体内膜中发挥蛋白质插入和折叠的功能。所有成员都有一个由五个跨膜区域组成的保守区域。这些蛋白质介导了各种各样蛋白质的膜插入，从线粒体中的呼吸亚基、叶绿体中捕获光能的叶绿素结合蛋白到细菌中的ATP合酶亚基。本综述讨论了YidC/Alb3/Oxa1蛋白家族及其在膜插入中的功能，以及细菌YidC的两个新结构，这两个结构提示了该插入酶家族的膜插入机制。
