Laboratory for Modified Nucleic Acid Systems, Department of Chemistry, BK School of Molecular Science, Pohang University of Science and Technology, Pohang 790-784, South Korea.
Bioorg Med Chem Lett. 2011 Jan 15;21(2):704-6. doi: 10.1016/j.bmcl.2010.12.004. Epub 2010 Dec 7.
We report the highly improved version of quencher-free molecular beacon (QF-MB) system by using graphene oxide (GO) as an external quencher. This QF-MB/GO system provided a higher S/B ratio (31.0) relative to that (2.2) of the same system in the absence of GO, while retaining a high selectivity for fully matched over single-base-mismatched targets.
我们报告了一种新型的无淬灭剂分子信标（QF-MB）系统，该系统使用氧化石墨烯（GO）作为外部淬灭剂。与不含 GO 的相同系统相比，QF-MB/GO 系统的 S/B 比值（31.0）得到了显著提高，同时对完全匹配的靶标保持了高选择性，而对单碱基错配的靶标具有较高的特异性。
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