Ruan Zhenchao, Zhao Yao, Yan Lili, Chen Hongyan, Fan Weiwei, Chen Juxiang, Wu Qihan, Qian Ji, Zhang Tianbao, Zhou KeKe, Mao Yin, Zhou Liangfu, Huang Yan, Lu Daru
State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai, People's Republic of China.
Front Biosci (Elite Ed). 2011 Jan 1;3(1):33-45. doi: 10.2741/e217.
Gliomas are aggressive brain tumor. Association studies were consistent for an inverse association between asthma and allergic conditions (IgE levels) and risk of glioma. Studies reported that the IL-4Ra, IL-13 and STAT6 genes played a relatively strong role in IgE production or allergy. This population-based case-control study aimed to find potential association between single nucleotide polymorphisms IL-13rs20541, IL-4Rars1801275 and glioma susceptibility in population, as well as STAT6 rs1059513 and STAT6 rs324015. Among non-smokers, homozygote GG of STAT6 4610A/G showed an increased association with risk of glioma compared with AA (adjusted OR=1.691, 95%CI=1.152-2.481, p=0.007, corrected p=0.028), and the haplotype with A allele at rs1059513 and G allele at rs324015 was revealed to increase glioma risk significantly (OR=1.321,95%CI= 1.081-1.614, p=0.007,corrected p=0.028). GG genotype of STAT6 4610A/G was a significant risk factor compared with AA in glioblastoma (adjusted OR=1.856, 95%CI=1.153-2.987, p=0.011, corrected p=0.044). GG of STAT6 4610A/G was significantly related to increased WHO IV risk compared with AA (adjusted OR=1.591,95%CI=1.030-2.459, p=0.036, corrected p=0.144). Interaction between IL-13 Arg130Gln and IL-4Ra Gln576Arg was observed in decreasing glioma risk (p=0.045).
胶质瘤是侵袭性脑肿瘤。关联研究一致表明哮喘和过敏状况（免疫球蛋白E水平）与胶质瘤风险之间存在负相关。研究报告称，白细胞介素-4受体α（IL-4Ra）、白细胞介素-13（IL-13）和信号转导及转录激活因子6（STAT6）基因在免疫球蛋白E产生或过敏中发挥了相对较强的作用。这项基于人群的病例对照研究旨在探寻单核苷酸多态性IL-13 rs20541、IL-4Ra rs1801275与人群中胶质瘤易感性之间的潜在关联，以及STAT6 rs1059513和STAT6 rs324015与胶质瘤易感性之间的潜在关联。在不吸烟者中，与AA基因型相比，STAT6 4610A/G的纯合子GG基因型与胶质瘤风险的关联增加（校正比值比=1.691，95%置信区间=1.152-2.481，p=0.007，校正p=0.028），并且显示rs1059513处为A等位基因且rs324015处为G等位基因的单倍型会显著增加胶质瘤风险（比值比=1.321，95%置信区间=1.081-1.614，p=0.007，校正p=0.028）。与AA基因型相比，在胶质母细胞瘤中，STAT6 4610A/G的GG基因型是一个显著的风险因素（校正比值比=1.856，95%置信区间=1.153-2.987，p=0.011，校正p=0.044）。与AA基因型相比，STAT6 4610A/G的GG基因型与世界卫生组织（WHO）IV级风险增加显著相关（校正比值比=1.591，95%置信区间=1.030-2.459，p=0.036，校正p=0.144）。观察到IL-13 Arg130Gln与IL-4Ra Gln576Arg之间在降低胶质瘤风险方面存在相互作用（p=0.045）。
