Zhao Hongyu, Cai Weisong, Su Shitao, Zhi Debao, Lu Jie, Liu Shuo
Department of Neurosurgery, Shengjing Hospital, China Medical University, Shenyang, China,
Tumour Biol. 2014 Apr;35(4):3875-80. doi: 10.1007/s13277-013-1514-4. Epub 2013 Dec 18.
Many studies have investigated the association between the allergic conditions and the risk of glioma. However, the evidence is inadequate to draw robust conclusions because most studies were generally small and conducted in heterogeneous populations. To shed light on these inconclusive findings, we conducted a meta-analysis of studies relating the allergic conditions to the risk of glioma. We identified the relevant studies by searching ISI Web of Science, PubMed, EMBASE, Chinese National Knowledge Infrastructure (CNKI) databases, and Wanfang database by October 2013. We included studies that reported odds ratio (OR) or hazard ratio (HR) with its 95% confidence interval (CI) for the association between the allergic condition and the risk of glioma. Eighteen independent publications, with 9,986 glioma cases and 118,950 controls, were included. Our results showed that allergic condition was reversely associated with the risk of glioma (OR = 0.78, 95% CI 0.73-0.83, P < 0.001). The results of our meta-analysis indicated that allergic conditions significantly reduce the risk of glioma.
许多研究调查了过敏状况与胶质瘤风险之间的关联。然而，证据并不充分，难以得出有力结论，因为大多数研究规模普遍较小，且是在异质性人群中开展的。为了阐明这些尚无定论的研究结果，我们对有关过敏状况与胶质瘤风险的研究进行了一项荟萃分析。我们通过检索截至2013年10月的科学引文索引（ISI）科学网、PubMed、EMBASE、中国知网（CNKI）数据库和万方数据库来确定相关研究。我们纳入了报告过敏状况与胶质瘤风险之间关联的比值比（OR）或风险比（HR）及其95%置信区间（CI）的研究。共纳入18篇独立出版物，其中包括9986例胶质瘤病例和118950例对照。我们的结果显示，过敏状况与胶质瘤风险呈负相关（OR = 0.78，95% CI 0.73 - 0.83，P < 0.001）。我们的荟萃分析结果表明，过敏状况显著降低了患胶质瘤的风险。
