AlShakweer Wafa, Alwelaie Yazeed, Mankung Aaron M, Graeber Manuel B
Division of Neuropathology, Department of Pathology and Clinical Laboratory Medicine, Faculty of Medicine, King Fahad Medical City, Riyadh, Kingdom of Saudi Arabia.
Front Biosci (Elite Ed). 2011 Jan 1;3(1):371-9. doi: 10.2741/e252.
Tumour associated macrophages (TAMs) are increasingly recognized as supporters of tumour growth. The present study was undertaken to examine benign pilocytic astrocytomas (PAs) for the presence of M2 macrophages. We have asked the question whether TAMs in PAs share the predominant CD163 immunophenotype with tumour-associated microglia/macrophages of malignant gliomas. In addition, we were interested in the question whether there is evidence that the macrophages in PAs derive from resident microglia in surrounding normal brain or whether cells expressing a macrophage phenotype may invade PAs from the vasculature. The latter question is of great interest with regard to so-called "bone marrow-derived microglia" (BMDM) which may provide a physiological route of entry into the CNS that could be used for novel cell-based treatments of brain cancer. In fact, we have found strong morphological evidence for such macrophage recruitment into PAs. We propose therefore that PAs may be used as a model for the study of macrophage recruitment into gliomas. Importantly, our results also confirm that microglia/macrophage infiltration per se is not associated with malignant glioma behaviour.
肿瘤相关巨噬细胞（TAM）越来越被认为是肿瘤生长的支持者。本研究旨在检查良性毛细胞型星形细胞瘤（PA）中是否存在M2巨噬细胞。我们提出了一个问题，即PA中的TAM是否与恶性胶质瘤的肿瘤相关小胶质细胞/巨噬细胞具有相同的主要CD163免疫表型。此外，我们还对以下问题感兴趣：是否有证据表明PA中的巨噬细胞来源于周围正常脑组织中的常驻小胶质细胞，或者表达巨噬细胞表型的细胞是否可能从血管侵入PA。后一个问题对于所谓的“骨髓源性小胶质细胞”（BMDM）非常重要，它可能提供一种进入中枢神经系统的生理途径，可用于基于细胞的新型脑癌治疗。事实上，我们已经发现了这种巨噬细胞募集到PA中的有力形态学证据。因此，我们认为PA可作为研究巨噬细胞募集到胶质瘤中的模型。重要的是，我们的结果还证实，小胶质细胞/巨噬细胞浸润本身与恶性胶质瘤行为无关。
